What is Primary lateral sclerosis

Primary lateral sclerosis (PLS) is a rare neurological disorder that affects the upper motor neurons in the brain and spinal cord. It is characterized by progressive weakness and stiffness in the muscles, leading to difficulties with movement and coordination.

Unlike amyotrophic lateral sclerosis (ALS), PLS primarily affects the upper motor neurons, which are responsible for initiating voluntary muscle movements. This results in muscle weakness, spasticity, and a gradual decline in motor function.

PLS typically starts in the legs and gradually progresses to other parts of the body, such as the arms and face. Common symptoms include muscle stiffness, difficulty with balance and coordination, muscle spasms, and slurred speech.

Although the exact cause of PLS is unknown, it is believed to have a genetic component. However, most cases occur sporadically without a family history of the condition.

Currently, there is no cure for PLS, but treatment focuses on managing symptoms and improving quality of life. Physical therapy, assistive devices, and medications can help alleviate muscle stiffness and improve mobility.