What is Felty Syndrome

Felty Syndrome is a rare autoimmune disorder that primarily affects individuals with long-standing rheumatoid arthritis (RA). It is characterized by the triad of rheumatoid arthritis, an enlarged spleen (splenomegaly), and a low white blood cell count (neutropenia).

Rheumatoid arthritis is a chronic inflammatory condition that primarily affects the joints, causing pain, swelling, and stiffness. In Felty Syndrome, individuals with RA may develop additional symptoms such as fatigue, weight loss, and recurrent infections due to neutropenia.

Splenomegaly, or an enlarged spleen, is a key feature of Felty Syndrome. The spleen plays a role in filtering the blood and fighting infections. In this condition, the spleen becomes enlarged and may lead to abdominal discomfort or pain.

Neutropenia refers to a low white blood cell count, specifically a decrease in neutrophils, which are important in fighting off bacterial infections. This can make individuals more susceptible to infections, particularly in the respiratory and urinary tracts.

Treatment for Felty Syndrome typically involves managing the underlying rheumatoid arthritis and addressing any associated complications. Medications such as disease-modifying antirheumatic drugs (DMARDs) and immunosuppressants may be prescribed to control inflammation and improve symptoms. In severe cases, splenectomy (surgical removal of the spleen) may be considered.