Yes it can definitely cause depression due to not being able to work your social life can be affected because you can't go out due to the brightness you need to be inside it and the pain is debilitating you don't feel like socializing you can't socialize for some who lose their eye they can be very depressed AK can lead to other types of diseases like trigeminal neuralgia which is known as a suicide disease so there are lots of different depressions some psychiatrists have said you need to Grieve the old person that you once were.