11

Is Achalasia hereditary?

Here you can see if Achalasia can be hereditary. Do you have any genetic components? Does any member of your family have Achalasia or may be more predisposed to developing the condition?

Is Achalasia hereditary?

Achalasia is a rare disorder that affects the esophagus, causing difficulty in swallowing. While the exact cause is unknown, research suggests that there may be a genetic component involved. Studies have shown that some individuals with achalasia have a family history of the condition, indicating a potential hereditary link. However, more research is needed to fully understand the genetic factors contributing to achalasia.



Achalasia is a rare disorder that affects the esophagus, the tube that carries food from the mouth to the stomach. It is characterized by the inability of the lower esophageal sphincter (LES) to relax and allow food to pass into the stomach. This results in difficulty swallowing, regurgitation of food, chest pain, and sometimes weight loss.



When it comes to the hereditary nature of achalasia, research suggests that there may be a genetic component involved. While the exact cause of achalasia is still unknown, studies have shown that there is a higher incidence of the condition in certain families, indicating a possible inheritance pattern.



Several genes have been identified as potential contributors to the development of achalasia. One of these genes is called the FLNA gene, which provides instructions for making a protein involved in the structure and function of cells. Mutations in this gene have been found in some individuals with achalasia, suggesting a genetic link.



Another gene that has been implicated in achalasia is the CREB-regulated transcription coactivator 1 (CRTC1) gene. Variations in this gene have been associated with an increased risk of developing achalasia. The CRTC1 gene is involved in regulating the expression of certain genes that play a role in muscle function, including the muscles of the esophagus.



While these genetic findings provide valuable insights into the potential hereditary nature of achalasia, it is important to note that not all cases of achalasia are caused by genetic factors. Other factors, such as environmental triggers or autoimmune responses, may also contribute to the development of the condition.



It is also worth mentioning that achalasia can occur sporadically, meaning it can occur in individuals with no family history of the condition. This suggests that there may be other factors at play in the development of achalasia.



In conclusion, while achalasia may have a hereditary component, the exact genetic mechanisms underlying the condition are still being investigated. The FLNA and CRTC1 genes have been identified as potential contributors, but further research is needed to fully understand the genetic basis of achalasia. It is important for individuals with a family history of achalasia to be aware of the potential risk and seek medical attention if they experience symptoms associated with the condition.


Diseasemaps
6 answers
There are now reports available online to suggest that this disease Achalasia can happen for different reasons. It can be difficult for your doctor to find a specific cause. This condition may be hereditary, or it may be the result of an autoimmune condition. With this type of condition, your body’s immune system mistakenly attacks healthy cells in your body. The degeneration of nerves in your esophagus often contributes to the advanced symptoms of achalasia.

Source: http://www.healthline.com/health/achalasia#overview1

Posted Sep 20, 2017 by Teresa 3050
Its possible. There is not sufficient research on the hereditary component yet.

Posted Oct 27, 2017 by JLMcK 5550
Not that they know. I am adopted.

Posted Jul 14, 2020 by Gina Manion 2500
No it's not hereditary

Posted Aug 16, 2022 by [email protected] 2500
Translated from spanish Improve translation
IT IS NOT HEREDITARY,THE CAUSE IS STILL UNKNOWN.

Posted Aug 22, 2017 by Lorena 2250

Is Achalasia hereditary?

Achalasia life expectancy

What is the life expectancy of someone with Achalasia?

9 answers
Celebrities with Achalasia

Celebrities with Achalasia

3 answers
Is Achalasia contagious?

Is Achalasia contagious?

8 answers
Natural treatment of Achalasia

Is there any natural treatment for Achalasia?

6 answers
ICD9 and ICD10 codes of Achalasia

ICD10 code of Achalasia and ICD9 code

7 answers
Living with Achalasia

Living with Achalasia. How to live with Achalasia?

8 answers
Achalasia diet

Achalasia diet. Is there a diet which improves the quality of life of peopl...

8 answers
History of Achalasia

What is the history of Achalasia?

6 answers

World map of Achalasia

Find people with Achalasia through the map. Connect with them and share experiences. Join the Achalasia community.

Stories of Achalasia

ACHALASIA STORIES
Achalasia stories
I started with strong chest pains in January 2016, like a heart attack. My doctor gave me Gaviscon Advance which helped me (and still helps) so I proceeded with my life. Then the first difficulties in swallowing. I needed to eat so slowly trying to ...
Achalasia stories
It all started with the hickups, for me that was quite strange i never hickcupped. We all though it quite funny at the time. "You eat too fast and dont talk while eating", mum said. At first it was only now and then, it became more frequent until eve...
Achalasia stories
It all began the day before I was moving to Australia, April 2000. I woke up the night before my flight with what I initially thought was heartburn (common mistake). Grabbed some cold water and that it was it - or so I thought. In Sydney, my first da...
Achalasia stories
GROWING UP I GOT INTO EXTREME SPORTS. MAINLY BMX AND SKATEBOARDING. I LOVED TO JUMP. RAMPS, CURBS,  EVEN OVER PEOPLE. ALL I WANTED TO DO WAS GET AIR. AFTER SCHOOL IT WAS HOME WORK(SOMETIMES) THEN TO BIKE. ONE WEEKEND WE WENT TO VISIT FAMILY. MY COUS...
Achalasia stories
Always had issues with food, to which I was labelled fussy. Suffered until I was 28 and had a doctor who could see that something was not right and made me have test after test to get to the bottom of it. Finally got a diagnosis just as I was about...

Tell your story and help others

Tell my story

Achalasia forum

ACHALASIA FORUM

Ask a question and get answers from other users.

Ask a question

Find your symptoms soulmates

From now on you can add your symptoms in diseasemaps and find your symptoms soulmates. Symptoms soulmates are people with similar symptoms to you.

Symptoms soulmates

Add your symptoms and discover your soulmates map

Soulmates map