Which are the symptoms of Acromegaly?

Symptoms of Acromegaly

Acromegaly is a rare hormonal disorder that occurs when the pituitary gland in the brain produces excessive growth hormone (GH). This excess GH leads to the overgrowth of bones and tissues in the body. The symptoms of acromegaly can vary from person to person, and they usually develop slowly over time. Early diagnosis and treatment are crucial to prevent complications and improve quality of life.

Physical Changes

One of the most noticeable symptoms of acromegaly is the gradual enlargement of certain body parts. These physical changes typically occur in adulthood, after the closure of the growth plates. The most commonly affected areas include:

• Hands and Feet: The bones in the hands and feet enlarge, resulting in increased shoe and ring sizes. The fingers and toes may become thicker and wider.


• Facial Features: The facial bones and soft tissues grow, leading to a coarsening of facial features. This may include a protruding jaw, enlarged nose, thickened lips, and widely spaced teeth.


• Head and Skull: The skull may become larger, and the forehead and brow ridge may protrude.

Internal Organ Enlargement

Acromegaly can also cause the enlargement of internal organs, which can lead to various complications. Some of the affected organs include:

• Heart: The heart muscles thicken, leading to an increased risk of high blood pressure, heart disease, and heart failure.


• Lungs: The respiratory system may be affected, causing sleep apnea or other breathing difficulties.


• Liver, Kidneys, and Spleen: These organs may enlarge, potentially causing abdominal pain and affecting their normal functions.

Joint and Bone Problems

Excess growth hormone can lead to joint and bone problems in individuals with acromegaly. These may include:

• Arthritis: The enlarged bones and tissues can put pressure on joints, leading to pain, stiffness, and limited mobility.


• Carpal Tunnel Syndrome: The compression of nerves in the wrist can cause numbness, tingling, and weakness in the hands.


• Spinal Changes: Overgrowth of bones in the spine can result in spinal stenosis, a condition where the spinal canal narrows and puts pressure on the spinal cord and nerves.

Other Symptoms

In addition to the physical changes, acromegaly can cause various other symptoms, including:

• Thickened, Oily Skin: The skin may become thicker, oilier, and more prone to acne.


• Excessive Sweating: Increased perspiration, particularly at night, is common.


• Headaches: Persistent headaches, often due to the enlargement of the skull, can occur.


• Visual Changes: Pressure on the optic nerves can lead to vision problems, such as peripheral vision loss or double vision.


• Fatigue and Weakness: Many individuals with acromegaly experience fatigue, weakness, and reduced stamina.


• Changes in Menstrual Cycle: Women may experience irregular menstrual periods or even infertility.

If you suspect you may have acromegaly or are experiencing any of these symptoms, it is important to consult a healthcare professional for a proper diagnosis and appropriate treatment. Early intervention can help manage symptoms, prevent complications, and improve overall well-being.