What is Acromegaly

Acromegaly is a rare hormonal disorder that occurs when the pituitary gland, located at the base of the brain, produces excessive growth hormone (GH). This condition usually develops in adulthood, after the growth plates have closed. The excess GH stimulates the liver to produce another hormone called insulin-like growth factor 1 (IGF-1), which leads to abnormal growth in various tissues and organs.

Common symptoms of acromegaly include enlarged hands and feet, facial changes (such as a protruding jaw or enlarged nose), joint pain, thickened skin, and deepening of the voice. Other complications may arise, including cardiovascular problems, diabetes, sleep apnea, and an increased risk of certain tumors.

Diagnosis typically involves blood tests to measure GH and IGF-1 levels, as well as imaging studies like MRI or CT scans to locate any pituitary tumors. Treatment options for acromegaly include surgery to remove the tumor, medications to reduce GH production or block its effects, and radiation therapy in some cases.

Early detection and treatment are crucial to prevent further complications and improve quality of life for individuals with acromegaly.