Adams-Oliver Syndrome, also known as AOS, is a rare genetic disorder characterized by a combination of skin abnormalities and malformations of the limbs or digits. While it is commonly referred to as Adams-Oliver Syndrome, there are no widely recognized synonyms for this specific condition.
Adams-Oliver Syndrome is named after the physicians who first described it in medical literature, Dr. William Adams and Dr. Robert Oliver, in the early 1960s. It is a congenital disorder, meaning it is present at birth, and its exact cause is still not fully understood.
Individuals with Adams-Oliver Syndrome typically exhibit a range of symptoms, including scalp defects such as missing patches of skin or thinning hair, cutis marmorata telangiectatica congenita (a skin condition characterized by a marbled appearance and dilated blood vessels), and transverse limb defects such as missing fingers or toes, or underdeveloped limbs.
The severity of Adams-Oliver Syndrome can vary widely among affected individuals. Some may only have mild skin and limb abnormalities, while others may experience more significant complications, such as cardiovascular defects or developmental delays.
Diagnosis of Adams-Oliver Syndrome is typically based on clinical evaluation, medical history, and imaging studies. Genetic testing may also be conducted to identify specific gene mutations associated with the condition.
Although there are no known synonyms for Adams-Oliver Syndrome, it is important to note that there are other genetic disorders and syndromes that may share some similar features or symptoms. These include ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC syndrome), split hand-foot malformation, and congenital scalp defects.
Management of Adams-Oliver Syndrome involves a multidisciplinary approach, addressing the specific needs of each individual. Treatment may include surgical interventions to correct limb malformations, management of associated medical conditions, and supportive therapies to promote optimal development and quality of life.