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Which are the causes of Adult-onset Stills Disease?

See some of the causes of Adult-onset Stills Disease according to people who have experience in Adult-onset Stills Disease

Adult-onset Stills Disease causes

Causes of Adult-onset Still's Disease


Adult-onset Still's Disease (AOSD) is a rare systemic inflammatory disorder that primarily affects adults. The exact cause of AOSD is still unknown, and researchers believe that it is likely to be multifactorial, involving a combination of genetic, environmental, and immunological factors.



Genetic Factors


Genetic predisposition is thought to play a role in the development of AOSD. Studies have shown that certain genetic variations may increase the susceptibility to the disease. The human leukocyte antigen (HLA) system, which plays a crucial role in the immune response, has been implicated in AOSD. Specifically, the HLA-DRB1 gene has been associated with an increased risk of developing AOSD. However, it is important to note that having these genetic variations does not guarantee the development of the disease, and other factors are likely involved.



Immunological Factors


Abnormal immune system responses are believed to contribute to the development of AOSD. The immune system normally protects the body from harmful substances, such as bacteria and viruses. In AOSD, the immune system mistakenly identifies the body's own tissues as foreign and launches an immune response, leading to inflammation and other symptoms. The exact trigger for this abnormal immune response is still unclear, but it is thought to involve a combination of genetic and environmental factors.



Environmental Factors


Environmental factors may also play a role in the development of AOSD. Infections, such as viral or bacterial infections, have been suggested as potential triggers for the disease. It is believed that certain infections may activate the immune system, leading to the development of AOSD in individuals who are genetically predisposed. However, more research is needed to establish a definitive link between specific infections and AOSD.



Inflammatory Pathways


Research has shown that various inflammatory pathways are dysregulated in AOSD. Interleukin-1 (IL-1) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of AOSD. Elevated levels of IL-1 have been observed in individuals with AOSD, contributing to the systemic inflammation and symptoms associated with the disease. Other cytokines, such as IL-6 and tumor necrosis factor-alpha (TNF-alpha), have also been implicated in the inflammatory process of AOSD.



Stress and Triggers


Stress and certain triggers have been reported to exacerbate the symptoms of AOSD. Emotional or physical stress, as well as certain medications, can potentially worsen the disease activity. Additionally, some individuals with AOSD may experience flare-ups triggered by factors such as cold weather, physical exertion, or hormonal changes. However, it is important to note that these triggers may vary among individuals, and not everyone with AOSD will experience the same response.



Conclusion


Adult-onset Still's Disease is a complex condition with an unclear etiology. While the exact cause of AOSD remains unknown, it is likely to involve a combination of genetic, environmental, and immunological factors. Genetic predisposition, abnormal immune responses, environmental triggers, dysregulated inflammatory pathways, and stress may all contribute to the development and progression of AOSD. Further research is needed to gain a deeper understanding of the underlying causes of AOSD, which could potentially lead to improved diagnostic methods and targeted treatments.


Diseasemaps
6 answers
No know origin

Posted Sep 28, 2017 by Pando1124 400
Doctors don't know for sure what causes Stills disease, it could have been a virus or even something as simple as food poisoning, the immune system over reacts within a Stills patient and goes on the rampage, it attacks the patients own connective tissue.

Posted Feb 25, 2019 by Terry 2550
No known cause, but some things viruses may cause it.

Posted Sep 29, 2019 by Jenifer E 4550
There is no definitive known cause however experts believe an infection triggers the condition within your body and your immune system responds by thinking there is something wrong even when you do not have any infection etc, and so it then starts attacking healthy cells etc causing you to have a variety of symptoms including joint pains, inflamed walls of the heart, temperature, sore throat, salmon coloured rashes etc

Posted Jan 21, 2021 by Lina 850
Translated from spanish Improve translation
You don't know the real causes, it has been said that something can be genetic or can be triggered by a virus or bacteria, but nothing is proven yet.

Posted Oct 18, 2017 by Paula Andrea 2750

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Stories of Adult-onset Stills Disease

ADULT-ONSET STILLS DISEASE STORIES
Adult-onset Stills Disease stories
Diagnosed with systemic-onset JRA in 1990, now known as systemic-onset juvenile idiopathic arthritis (SJIA). After a period of remission for a number of years as an adult I presented to ER with a serious flare and they wouldn't listen to me AT ALL ab...
Adult-onset Stills Disease stories
I began feeling a pain in my ankle at 23. I  had a c-section the year before and in that same year, I was mildly electrocuted twice. I thought I'd mention this, but am told that has nothing to do with the diagnoses. I was on steroids for many years ...
Adult-onset Stills Disease stories
My ankle swelled like I'd been bitten by a spider when I was 7yrs old. Spiking fevers, rash & other swollen joints followed. Many hospitals, tests & Drs later Dx JRA. Adult doses of steroids & many other Rxs continued until I went into remission in m...
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Diagnosticada de enfermedad de Still a los 20 años.  Tratamiento con MTX. 
Adult-onset Stills Disease stories
Started in May of 2009, while at a meeting for work I had a fever and overall sick feeling when I got to my hotel room.delt with it slept until the next day and all was fine. Same thing happened the next day in the afternoon and evening. This went o...

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