Which are the symptoms of Amyloidosis?

Symptoms of Amyloidosis

Amyloidosis is a rare and complex group of diseases characterized by the abnormal accumulation of amyloid proteins in various organs and tissues throughout the body. These proteins can disrupt normal organ function and cause a wide range of symptoms. The specific symptoms experienced by individuals with amyloidosis can vary depending on the organs affected and the extent of the disease. Here are some of the common symptoms associated with amyloidosis:

General Symptoms:

• Fatigue: Many individuals with amyloidosis experience persistent fatigue and a general feeling of weakness.


• Weight loss: Unexplained weight loss may occur due to the impact of amyloid deposits on the digestive system.


• Swelling: Swelling, particularly in the ankles and legs, can occur as a result of fluid retention caused by impaired organ function.


• Shortness of breath: Amyloid deposits in the heart or lungs can lead to difficulty breathing and shortness of breath.


• Easy bruising and bleeding: Amyloidosis can affect blood clotting, leading to easy bruising, bleeding gums, or nosebleeds.

Cardiac Symptoms:

• Heart palpitations: Irregular heartbeats, rapid heart rate, or a sensation of fluttering in the chest may occur.


• Shortness of breath: As amyloid deposits accumulate in the heart, it can lead to heart failure and subsequent difficulty breathing.


• Chest pain: Some individuals may experience chest pain or discomfort due to reduced blood flow to the heart.

Renal Symptoms:

• Proteinuria: Amyloid deposits in the kidneys can cause protein to leak into the urine, resulting in proteinuria.


• Swelling: Edema or swelling in the legs, ankles, or around the eyes can occur due to impaired kidney function.


• Decreased urine output: The kidneys may produce less urine, leading to decreased frequency of urination.

Gastrointestinal Symptoms:

• Diarrhea or constipation: Amyloidosis can affect the digestive system, leading to alternating episodes of diarrhea and constipation.


• Nausea and vomiting: Some individuals may experience persistent nausea and vomiting.


• Loss of appetite: The impact of amyloid deposits on the digestive system can result in a decreased appetite and unintentional weight loss.

Neurological Symptoms:

• Numbness or tingling: Peripheral neuropathy, characterized by numbness, tingling, or pain in the extremities, can occur.


• Weakness: Muscle weakness or loss of coordination may be present.


• Dizziness or fainting: Amyloidosis can affect the autonomic nervous system, leading to dizziness or fainting spells.

Other Symptoms:

• Enlarged tongue: The tongue may become enlarged and firm, making it difficult to speak or swallow.


• Skin changes: Amyloid deposits in the skin can cause purpura (small purple spots) or waxy patches.


• Enlarged liver or spleen: In some cases, the liver or spleen may become enlarged due to amyloid deposition.

It is important to note that the symptoms of amyloidosis can mimic those of other diseases, making diagnosis challenging. If you experience any persistent or concerning symptoms, it is crucial to consult a healthcare professional for a proper evaluation and diagnosis.