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Which are the causes of Ankylosing Spondylitis?

See some of the causes of Ankylosing Spondylitis according to people who have experience in Ankylosing Spondylitis

Ankylosing Spondylitis causes

Ankylosing Spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine, causing pain, stiffness, and eventually leading to fusion of the vertebrae. While the exact cause of AS is still unknown, researchers believe that a combination of genetic and environmental factors play a role in its development.



Genetic Factors


Genetics is considered to be a significant factor in the development of Ankylosing Spondylitis. The disease has a strong genetic component, as it tends to run in families. The majority of individuals with AS carry a specific gene called HLA-B27, which is present in about 90% of people with AS. However, having the HLA-B27 gene does not guarantee the development of AS, as many people with this gene never develop the disease. This suggests that other genetic factors may also be involved.



Immune System Dysfunction


AS is classified as an autoimmune disease, which means that the immune system mistakenly attacks healthy tissues in the body. In the case of AS, the immune system primarily targets the joints and ligaments of the spine. The exact trigger for this immune system dysfunction is still unknown, but it is believed to be a combination of genetic predisposition and environmental factors.



Environmental Factors


While genetics play a significant role, environmental factors are also thought to contribute to the development of Ankylosing Spondylitis. Some potential environmental triggers include:




  • Infections: Certain bacterial infections, such as those caused by Klebsiella pneumoniae or Escherichia coli, have been linked to the development of AS. These infections may trigger an immune response that leads to the inflammation seen in AS.

  • Smoking: Smoking has been identified as a risk factor for developing AS. It is believed that smoking may worsen the disease and increase the severity of symptoms.

  • Stress: While not a direct cause, stress can potentially exacerbate the symptoms of AS. Stress can weaken the immune system and increase inflammation, leading to increased pain and stiffness.

  • Physical Trauma: Injury or trauma to the spine may trigger the onset of AS in individuals who are genetically predisposed to the disease. However, not all individuals who experience spinal trauma will develop AS.



Conclusion


In summary, Ankylosing Spondylitis is a complex disease with multiple contributing factors. While the exact cause remains unknown, it is believed that a combination of genetic predisposition and environmental triggers, such as infections, smoking, stress, and physical trauma, play a role in its development. Further research is needed to fully understand the underlying mechanisms of AS and to develop more effective treatments for this chronic condition.


Diseasemaps
19 answers
There is no consensus on that one.

Citing from Mayo clinic website:
"Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition.

Risk factors

Your sex. Men are more likely to develop ankylosing spondylitis than are women.
Your age. Onset generally occurs in late adolescence or early adulthood.
Your heredity. Most people who have ankylosing spondylitis have the HLA-B27 gene. But many people who have this gene never develop ankylosing spondylitis."

Posted Mar 4, 2017 by kat1 1050
Research continues to try and breakthru what the actually causes are but it is known that it is mainly genetically acquired and hereditery by HLA-B27 gene. Not everyone with the gene with end up becoming active with the disease though. Environmental factors are also thought to be a factor and the immune system is a biggie. They believe if stress or trauma even perhaps a bacterial infection of some sort occurs it activates the disease and causes the inflammation and when this occurs the bodies immune system never really recovers. It is active. Not everyone person is the same either. What one person may have may be totally different from the next. So everyone can experience different signs and symptoms and progression.

Posted Mar 5, 2017 by Heather 1120
Not sure. It can be hereditary.

Posted May 17, 2017 by Shannon 1050
I dont know that there is a clear definitive answer here though there appears to be a genetic relationship to some interlukeins and the hla-b27 genetic marker.

Posted May 17, 2017 by Keli 1050
It's genetic

Posted May 18, 2017 by Karlie 1150
There is no recognised cause. It is believed that the immune system responds to something and goes into over drive. It then never turns off. One of the suspected caused is bacteria in the bowel.

Posted May 19, 2017 by Kylie Frost 2120
For me it was an antibiotic !

Posted May 19, 2017 by Tamra 1750
Too active immune systems. Could be different things for different people.

Posted Jul 24, 2017 by 1000
could be genetic or could be caused by an unknown virus

Posted Aug 31, 2017 by BigStu111 12832
Although there are no known causes to Spondylitis, and injury and environment with the right genetic make up is the general answer. Since 2015 gut bacteria by certain foods and infections have been studied with promising results.

Posted Sep 6, 2017 by Daniel Wilson 2010
It is thought to be genetic that causes it.

Posted Sep 7, 2017 by Luciano Scariano 2600
From all the data I've read and talked about with my rheumy, there is no known reason for the cause of AS; however the HBL-A27 gene is associated with the disease...you can have the gene but not get AS and vice verse...interesting to say the least.

Posted Sep 10, 2017 by Sal 4050
Just Deficiency of Diet ingredients Omega 3 5 7 9 Example Vitamins Calcium Zinc etc

Posted Sep 21, 2017 by Rana Navid Anwaar Khan 3945
Non esistono cause specifiche
È una predisposizione genetica che può essere scatenata da molti fattori

Posted Oct 1, 2017 by Silvia 2500
On the day of today there is not evidence yet of the causes. Although scientists seems to agree it could be a combination of factors as genetics and environment.
It is also discussed that it can be triggered by an infection or by a macrobiotic issue.

But causes remains unknown on the day of today.

Posted Feb 16, 2018 by Laeti 3570
It is genetic, but can be triggered by infection or other environmental factors.

Posted May 31, 2018 by Colleen 2550
Translated from portuguese Improve translation
Unfortunately I cannot answer these questions

Posted Aug 10, 2017 by Andressa 1050
Translated from portuguese Improve translation
I believe that it is genetic

Posted Aug 15, 2017 by Adriana 1000

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Hello.  My name is Guyla Galindo. I’m 62 years old and live in Washington state. I have ankylosing spondylitis (AS), lupus, fibromyalgia, chronic ptsd/depression, and polycystic kidney disease. I remember http://thefacesofankylosingspondylit...
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11/01/2015 After a trip to the Emergency Room with severe pain and limited mobility on New Year’s morning of 2013, a visit to my primary care physician and a referral to a bone specialist resulting in a positive test for the HLA-B27 gene marker an...
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Not really a story, been having troubles with my back and hips since I was a kid.    And about 2years ago, I finally got diagnosed with Ankylosing Spondylitis, and have been undergoing treatment for it. Tried a bunch and failed, so always somethi...
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Diagnosed in 2003, after having my daughter in 2002. The diagnosis process took sometime to do the differential.  Had much trouble with medications. Allergies in all antiTNF drugs. Last one almost "killed" me.  On and off from painkillers, trying...

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bonjour , va t il y avoir des nouveaux traitements rapidement ?

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