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Is Ankylosing Spondylitis hereditary?

Here you can see if Ankylosing Spondylitis can be hereditary. Do you have any genetic components? Does any member of your family have Ankylosing Spondylitis or may be more predisposed to developing the condition?

Is Ankylosing Spondylitis hereditary?

Ankylosing Spondylitis (AS) has a strong genetic component. While the exact cause is unknown, inheritance of certain genes increases the risk of developing AS. The HLA-B27 gene is the most significant genetic factor associated with AS, but not everyone with this gene develops the condition. Other genetic and environmental factors may also contribute to the development of AS. Therefore, having a family history of AS increases the likelihood of inheriting the genetic predisposition for the disease.



Ankylosing Spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine, causing pain, stiffness, and eventually fusion of the vertebrae. It belongs to a group of conditions known as spondyloarthritis, which also includes other related diseases like psoriatic arthritis and reactive arthritis. AS typically starts in early adulthood and can have a significant impact on a person's quality of life.



One common question that arises when discussing AS is whether it is hereditary. The short answer is yes, there is a genetic component to the development of AS. However, it is important to note that genetics alone do not determine whether someone will develop the condition.



AS is strongly associated with a specific genetic marker called HLA-B27. HLA-B27 is a protein that plays a role in the immune system's ability to recognize and fight off infections. It is estimated that approximately 90% of individuals with AS carry the HLA-B27 gene, although having the gene does not guarantee the development of the disease.



Having a family history of AS also increases the likelihood of developing the condition. Studies have shown that individuals with a first-degree relative (such as a parent or sibling) who has AS are at a higher risk of developing the disease themselves. However, it is important to remember that even with a family history, many individuals with the genetic predisposition never develop AS.



While genetics play a role in the development of AS, other factors also contribute to the disease. Environmental factors, such as exposure to certain infections or toxins, may trigger the onset of AS in individuals who are genetically susceptible. The interplay between genetics and the environment is complex and not yet fully understood.



It is also worth noting that AS is more common in certain populations. For example, it is more prevalent in individuals of Caucasian descent compared to other ethnic groups. This suggests that there may be additional genetic factors at play, although further research is needed to fully understand these differences.



Diagnosing AS typically involves a combination of clinical evaluation, imaging tests (such as X-rays or MRI), and blood tests. While the presence of HLA-B27 can be a helpful diagnostic clue, it is not definitive, as some individuals with AS do not carry the gene, and not all individuals with the gene develop AS.



Treatment for AS focuses on managing symptoms, reducing inflammation, and preventing complications. This may include a combination of medications, physical therapy, exercise, and lifestyle modifications. Regular monitoring and follow-up with a healthcare professional are essential to ensure optimal management of the disease.



In conclusion, while Ankylosing Spondylitis has a genetic component and is more common in individuals with a family history of the disease, it is not solely determined by genetics. The presence of the HLA-B27 gene increases the risk but does not guarantee the development of AS. Environmental factors and other genetic factors likely play a role in the development of the disease. If you suspect you may have AS or have a family history of the condition, it is important to consult with a healthcare professional for proper evaluation and management.


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11 answers
It can run in families. It is believed that some genes make you predisposed to developing it

Posted May 19, 2017 by Kylie Frost 2120
Don't have an answer to this

Posted May 19, 2017 by Tamra 1750
yes, this is why we should get our children tested

Posted Aug 31, 2017 by BigStu111 12832
Yes, very hereditary. HLA-B27 and other B27 can be components which require testing.

Posted Sep 6, 2017 by Daniel Wilson 2010
It is hereditary, but you can be born with it to with no other family member with it.

Posted Sep 7, 2017 by Luciano Scariano 2600
It can be; Im the only person in my family with AS

Posted Sep 10, 2017 by Sal 4050
Yes It is Hereditary .100 pecent

Posted Sep 21, 2017 by Rana Navid Anwaar Khan 3945
No come tutte le malattie reumatiche non sono ereditarie

Posted Oct 1, 2017 by Silvia 2500
It can be. But then the possible components needs an environmental factor to be triggered.

But again, there is no proof yet of which genetic components with what or how can be triggered.
So although it may be hereditary, that doesn't mean that it will be passed on and also that it will be triggered.

Although when it comes to the diagnose, someone having already a parent suffering from this condition can be a good indication that maybe in this case the patient is also suffering from a related disease or the same.

Posted Feb 16, 2018 by Laeti 3570
Yes it can. HLA B27 is the marker for AS.

Posted May 31, 2018 by Colleen 2550

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bonjour , va t il y avoir des nouveaux traitements rapidement ?

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