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What are the latest advances in Ankylosing Spondylitis?

Here you can see the latest advances and discoveries made regarding Ankylosing Spondylitis.

Latest progress of Ankylosing Spondylitis

Ankylosing Spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine, causing pain, stiffness, and eventually leading to fusion of the vertebrae. While there is no cure for AS, significant advancements have been made in recent years to improve diagnosis, treatment, and management of the disease.



Genetic Discoveries


One of the major breakthroughs in understanding AS has been the identification of the HLA-B27 gene as a major genetic risk factor. Research has shown that over 90% of individuals with AS carry the HLA-B27 gene, although not everyone with the gene develops the disease. This discovery has not only helped in early diagnosis but has also provided insights into the underlying mechanisms of the disease.



Improved Imaging Techniques


Advancements in imaging techniques have greatly contributed to the early detection and monitoring of AS. Magnetic Resonance Imaging (MRI) has become an essential tool in diagnosing AS, allowing for the visualization of inflammation in the sacroiliac joints and spine. The use of MRI has significantly improved the accuracy of diagnosis, enabling early intervention and treatment.



Biologic Therapies


Biologic therapies have revolutionized the treatment of AS. These medications target specific molecules involved in the inflammatory process, such as tumor necrosis factor (TNF) or interleukin-17 (IL-17). Biologics have shown remarkable efficacy in reducing pain, inflammation, and improving physical function in patients with AS. They have also been effective in slowing down the progression of spinal fusion and improving overall quality of life.



Exercise and Physical Therapy


Exercise and physical therapy play a crucial role in managing AS. Recent studies have highlighted the importance of regular exercise in reducing pain, improving flexibility, and maintaining spinal mobility. Specific exercises, such as stretching, strengthening, and low-impact aerobic activities, have been found to be particularly beneficial for individuals with AS. Physical therapy programs tailored to the needs of AS patients have shown significant improvements in pain relief and functional ability.



Personalized Medicine


Advancements in genetic research have paved the way for personalized medicine in AS. By analyzing an individual's genetic profile, doctors can now predict the likelihood of disease progression and tailor treatment plans accordingly. This approach allows for more targeted therapies and better outcomes for patients.



Collaborative Research Efforts


Collaborative research efforts have played a vital role in advancing our understanding of AS. International collaborations and registries have been established to collect data on a large scale, enabling researchers to study the disease more comprehensively. These initiatives have led to the identification of new biomarkers, improved classification criteria, and the development of novel treatment strategies.



Emerging Therapies


Several emerging therapies show promise in the treatment of AS. JAK inhibitors, which target the Janus kinase pathway involved in inflammation, have shown positive results in clinical trials. Additionally, ongoing research is exploring the potential of other biologic agents and small molecules in managing AS. These advancements provide hope for more effective treatment options in the future.



Improved Patient Support


Efforts have been made to improve patient support and education for individuals with AS. Online resources, support groups, and patient advocacy organizations have provided platforms for sharing experiences, knowledge, and emotional support. These initiatives help patients navigate their journey with AS, empowering them to actively participate in their treatment decisions and improve their overall well-being.



In conclusion, significant progress has been made in the understanding and management of Ankylosing Spondylitis. Genetic discoveries, improved imaging techniques, biologic therapies, personalized medicine, collaborative research efforts, emerging therapies, and enhanced patient support have all contributed to advancing the field. These advancements offer hope for improved outcomes, better quality of life, and ultimately, a brighter future for individuals living with AS.


Diseasemaps
10 answers
There is new research and medications being researched to control the immune system. The idea of biologics is to suppress the immune system enough to stop the inflammatory response but not enough that the person cannot fight the common cold

Posted May 19, 2017 by Kylie Frost 2120
NSAID's , TNFs, PT and hydro therapy to name a few

Posted Aug 31, 2017 by BigStu111 12832
Advances in managing A.S. as well as with the diagnosis and treatment. New biologics like secukinumab and Simponi. Considerable advancements in identifying novel genetic associations and immune pathways.

Posted Sep 6, 2017 by Daniel Wilson 2010
There are large amount of medication able to help us who are affected with AS. So you got to test different ones to find something that works for you. But do not forget to be active and move around.

Posted Sep 7, 2017 by Luciano Scariano 2600
Earlier diagnosis has been an advancement and he onset of biologics/TNF blockers have been great advancements to managing this disease...looking for to hearing/reading more in advancements!

Posted Sep 10, 2017 by Sal 4050
Bio treatment which have a lot of side affects
Diet Plans but Not Exact diet plan yet.
Yes

Posted Sep 21, 2017 by Rana Navid Anwaar Khan 3945
Le cure sono sempre in continuo movimento grazie alla ricerca e all'immissione di nuovi farmaci biologici e innovativi

Posted Oct 1, 2017 by Silvia 2500
Whereas the biologics treatment have been one of the most advanced solution to slow down the disease, they were not yet directly made for only treating Ankylosing Spondylitis.

Today they are looking for drug that is more addressed for this condition.

A recent release is Secukinumab, trade name Cosentyx, which treats psoriasis, ankylosing spondylitis, and psoriatic arthritis.

Posted Feb 16, 2018 by Laeti 3570
The latest treatments in AS involve injectable TNF Inhibitors, Anti CD20 monoclonal antibody, DMARDS or disease modifying anti rhuematic drugs and numerous other injectable and oral immunosuppressive drugs. Various pain management injections and procedures performed by Anesthisiologists. Physical Therapy with ultrasound, TENS and hydotherapy.

Posted Jun 1, 2018 by Colleen 2550

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ANKYLOSING SPONDYLITIS STORIES
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Hello.  My name is Guyla Galindo. I’m 62 years old and live in Washington state. I have ankylosing spondylitis (AS), lupus, fibromyalgia, chronic ptsd/depression, and polycystic kidney disease. I remember http://thefacesofankylosingspondylit...
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11/01/2015 After a trip to the Emergency Room with severe pain and limited mobility on New Year’s morning of 2013, a visit to my primary care physician and a referral to a bone specialist resulting in a positive test for the HLA-B27 gene marker an...
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Starting with oldest to newest diagnosed.  IBS When I was 14 I started having stomach problems. Pain, nausea, vomiting, constipation, diarrhea. The worst was the pain. Went to my primary Dr and he thought it was an ulcer and treated me for that. I...
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Not really a story, been having troubles with my back and hips since I was a kid.    And about 2years ago, I finally got diagnosed with Ankylosing Spondylitis, and have been undergoing treatment for it. Tried a bunch and failed, so always somethi...
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Diagnosed in 2003, after having my daughter in 2002. The diagnosis process took sometime to do the differential.  Had much trouble with medications. Allergies in all antiTNF drugs. Last one almost "killed" me.  On and off from painkillers, trying...

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Anyone have breathing difficuties? I have COPD and Asthma and with the AS constricting my ribs, it is tough. I do the exercies but.....
Ankylosing Spondylitis forum
I have been recently diagnosed with AS. I believe I have been living with this for over 10 years undiagnosed. I guess I should be greatful to know this all hasn't just been all in my mind and I can hopefully get on the right treatment path but I'm ve...
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bonjour , va t il y avoir des nouveaux traitements rapidement ?

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