How do I know if I have Antiphospholipid / Hughes Syndrome?

Antiphospholipid syndrome (APS), also known as Hughes syndrome, is an autoimmune disorder that affects the blood's ability to clot properly. It is characterized by the presence of specific antibodies called antiphospholipid antibodies (aPL) in the blood. These antibodies mistakenly attack certain proteins that bind to phospholipids, which are essential components of cell membranes and blood clotting processes.

If you suspect you may have APS, it is important to consult with a healthcare professional for a proper diagnosis. Here are some signs and symptoms commonly associated with APS:

• Recurrent blood clots: APS can cause blood clots to form in veins or arteries, leading to conditions such as deep vein thrombosis (DVT), pulmonary embolism, or stroke. If you have experienced multiple unexplained blood clots, especially in unusual locations, it could be an indication of APS.


• Pregnancy complications: APS is known to increase the risk of pregnancy complications, including recurrent miscarriages, stillbirths, and pre-eclampsia. If you have a history of recurrent pregnancy loss or complications, APS might be a potential cause.


• Thrombocytopenia: APS can sometimes cause a decrease in the number of platelets in the blood, leading to a condition called thrombocytopenia. This can result in easy bruising, prolonged bleeding, or the formation of small red or purple spots on the skin.


• Other symptoms: APS can also manifest as a variety of other symptoms, such as migraines, cognitive difficulties, skin rashes, and heart problems. However, these symptoms can be non-specific and may be caused by other conditions as well.

If you experience any of these symptoms or have concerns about APS, it is crucial to seek medical advice. A healthcare professional will evaluate your medical history, perform a physical examination, and order specific blood tests to detect the presence of antiphospholipid antibodies. These tests typically include the lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies.

Remember, only a qualified healthcare provider can diagnose APS accurately. If you suspect you may have APS, it is essential to consult with a medical professional for appropriate evaluation, diagnosis, and management.