What is Antisynthetase syndrome

Antisynthetase syndrome is a rare autoimmune disorder that primarily affects the muscles and lungs. It is characterized by the presence of specific autoantibodies called antisynthetase antibodies, which target a group of enzymes called aminoacyl-tRNA synthetases. These enzymes play a crucial role in protein synthesis within cells.

The hallmark symptoms of Antisynthetase syndrome include muscle weakness, joint pain, and inflammation of the lungs (interstitial lung disease). Other possible manifestations may include skin rashes, fever, Raynaud's phenomenon, and arthritis. The syndrome predominantly affects adults, with a higher prevalence in women.

Early diagnosis and treatment are essential to manage Antisynthetase syndrome effectively. Treatment typically involves a multidisciplinary approach, including medications to suppress the immune system and reduce inflammation. Physical therapy and pulmonary rehabilitation may also be recommended to improve muscle strength and lung function.

While the exact cause of Antisynthetase syndrome remains unknown, it is believed to involve a combination of genetic and environmental factors. Research is ongoing to better understand the underlying mechanisms and develop targeted therapies for this complex autoimmune condition.