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What is the prevalence of Autoimmune Hemolytic Anemia / Cold Agglutinin Disease?

How many people does Autoimmune Hemolytic Anemia / Cold Agglutinin Disease affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Autoimmune Hemolytic Anemia / Cold Agglutinin Disease

Autoimmune Hemolytic Anemia (AIHA) is a rare condition characterized by the destruction of red blood cells by the immune system. Cold Agglutinin Disease (CAD) is a subtype of AIHA where the immune system attacks red blood cells in response to cold temperatures. The prevalence of AIHA is estimated to be around 1-3 cases per 100,000 individuals, with CAD accounting for approximately 15-20% of all AIHA cases. Although AIHA and CAD are relatively uncommon, they can have significant impacts on an individual's health and require proper diagnosis and management by healthcare professionals.

Autoimmune Hemolytic Anemia (AIHA) is a rare disorder characterized by the destruction of red blood cells (hemolysis) due to the body's immune system mistakenly attacking its own red blood cells. Cold Agglutinin Disease (CAD) is a specific type of AIHA where the immune system produces antibodies that bind to red blood cells at low temperatures, leading to their destruction.

The prevalence of AIHA varies depending on the population studied. In general, AIHA is considered a rare disease, with an estimated incidence of 1-3 cases per 100,000 individuals per year. CAD is even rarer, accounting for approximately 15-20% of all AIHA cases.

AIHA can affect individuals of any age, but it is more commonly diagnosed in adults, particularly those over the age of 40. It can occur as a primary condition or secondary to other underlying diseases, such as autoimmune disorders, infections, or malignancies.

While AIHA and CAD are relatively uncommon, it is important to recognize the potential signs and symptoms, including fatigue, pale skin, shortness of breath, and jaundice. Prompt diagnosis and appropriate treatment are crucial in managing these conditions and improving patient outcomes.
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World map of Autoimmune Hemolytic Anemia / Cold Agglutinin Disease

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Stories of Autoimmune Hemolytic Anemia / Cold Agglutinin Disease

AUTOIMMUNE HEMOLYTIC ANEMIA / COLD AGGLUTININ DISEASE STORIES
Autoimmune Hemolytic Anemia / Cold Agglutinin Disease stories
Our daughter was diagnosed at 2 months with AIHA.  Her hemoglobin was 62.  She recieved 3 blood transfusions at that point and was placed on steriods.  We were unable to taper her completely off of them for 10 months.  At 14 months of age she had...
Autoimmune Hemolytic Anemia / Cold Agglutinin Disease stories
diagnosed at 12, male.  AIHA of mixed warm and cold. Eventually Rituxan 4 rounds was given and had very good response - 2 years on very well.
Autoimmune Hemolytic Anemia / Cold Agglutinin Disease stories
Diagnosed November 2014 after feeling quite sick for months.  Hemoglobin was 62 and platelets low as well.  Was originally diagnosed with Evans Syndrome because platelets also being destroyed.  Prescribed prednisone 80 mgs and cyclosphosamide.  C...
Autoimmune Hemolytic Anemia / Cold Agglutinin Disease stories
I'v got warm AIHA. got in 2007. Done prednisone and rituxin. 
Autoimmune Hemolytic Anemia / Cold Agglutinin Disease stories
Our son, Austin, was diagnosed in December 2016 after inform us of blood in his urine. We were immediately rushed to ER and tested his urine, which was black. It was revealed that his urine contained a large amount of RBC's and his hemoglobin was 93(...

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