Autoimmune Hemolytic Anemia (AIHA) is a rare disorder characterized by the destruction of red blood cells (hemolysis) due to the body's immune system mistakenly attacking its own red blood cells. Cold Agglutinin Disease (CAD) is a specific type of AIHA where the immune system produces antibodies that bind to red blood cells at low temperatures, leading to their destruction.
The prevalence of AIHA varies depending on the population studied. In general, AIHA is considered a rare disease, with an estimated incidence of 1-3 cases per 100,000 individuals per year. CAD is even rarer, accounting for approximately 15-20% of all AIHA cases.
AIHA can affect individuals of any age, but it is more commonly diagnosed in adults, particularly those over the age of 40. It can occur as a primary condition or secondary to other underlying diseases, such as autoimmune disorders, infections, or malignancies.
While AIHA and CAD are relatively uncommon, it is important to recognize the potential signs and symptoms, including fatigue, pale skin, shortness of breath, and jaundice. Prompt diagnosis and appropriate treatment are crucial in managing these conditions and improving patient outcomes.