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Which are the causes of Biliary Atresia?

See some of the causes of Biliary Atresia according to people who have experience in Biliary Atresia

Biliary Atresia causes

Biliary atresia is a rare and serious liver disease that affects infants. It is characterized by the absence or underdevelopment of the bile ducts, which are responsible for carrying bile from the liver to the gallbladder and small intestine. Without proper bile flow, the liver becomes damaged, leading to liver failure if left untreated. The exact cause of biliary atresia is still unknown, but several factors have been identified as potential contributors to the development of this condition.



Possible Causes of Biliary Atresia:



1. Genetic Factors:


Research suggests that genetic factors may play a role in the development of biliary atresia. Certain genes or gene mutations may predispose infants to this condition. However, no specific gene has been identified as the sole cause of biliary atresia, indicating that it is likely a complex interplay of multiple genetic factors.



2. Autoimmune Response:


Some studies propose that biliary atresia could be triggered by an autoimmune response, where the body's immune system mistakenly attacks and damages the bile ducts. This theory suggests that an initial insult, such as a viral infection, may trigger the immune system to target the bile ducts, leading to their inflammation and subsequent obstruction.



3. Inflammatory Processes:


Inflammation within the bile ducts is a common feature of biliary atresia. It is believed that an abnormal immune response or an infection may cause inflammation, leading to the destruction and obstruction of the bile ducts. The exact triggers for this inflammatory process are still under investigation.



4. Maternal and Environmental Factors:


While the majority of cases of biliary atresia occur sporadically without any known cause, some studies suggest that certain maternal and environmental factors may contribute to its development. Maternal factors such as advanced maternal age, certain infections during pregnancy, and exposure to certain medications or toxins have been proposed as potential risk factors. However, more research is needed to establish a definitive link.



5. Viral Infections:


Some viral infections have been associated with an increased risk of biliary atresia. Researchers have identified the presence of viruses, such as cytomegalovirus (CMV) and reovirus, in the liver tissue of affected infants. It is hypothesized that these viruses may trigger an immune response that leads to the destruction of the bile ducts. However, the exact role of viral infections in the development of biliary atresia is still not fully understood.



6. Abnormal Development:


In a small number of cases, biliary atresia may result from abnormal development of the bile ducts during fetal development. This could be due to genetic abnormalities or disruptions in the signaling pathways that regulate the formation of the bile ducts. However, the specific mechanisms underlying this abnormal development are not yet fully elucidated.



It is important to note that while these factors have been identified as potential causes or contributors to biliary atresia, the exact cause may vary from case to case. Additionally, in many cases, the cause remains unknown, highlighting the need for further research to better understand this complex condition.


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BILIARY ATRESIA STORIES
Biliary Atresia stories
My name is Zach Branson. I was born to Kelly Jeanine Flowers and Todd Branson on January 2, 1987 in Grand Junction, CO. Within 1-2 weeks of my birth, I was diagnosed (in Denver) with biliary atresia. Biliary Atresia is a blockage in the tubes (duct...
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Born in South Korea with Biliary Atresia.  Kasai Procedure at 6 weeks old, now 5 years old.  Have been living in the US since age 3.  Currently on transplant list at Children's Hospital, Pittsburgh.
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my son leon was born September 2013 at 2 months old he was diagnosed with biliary atresia he had a kasia procedure that same month. A few months after it started to fail which resulted in having a liver transplant late 2014. He was in and out of hosp...
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Went in for a normal ultrasound at 21 weeks pregnant with Aubree, at the Army hospital on post, to find out if we were having a boy or a girl. They sent us to The Children's Hospital in Colorado Springs (where we lived at the time) because there was ...
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Our Girl was diagnosed before her second month, she have her KASAI on Nov 2010 and did't work we received a gift of life on 3-11 and because of complications she was listed again and received a second transplant one week after. We can help families...

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