C3 Glomerulopathy C3G synonyms

C3 Glomerulopathy (C3G) Synonyms

C3 Glomerulopathy (C3G) is a rare kidney disorder characterized by abnormal deposits of a protein called C3 in the glomeruli, which are the tiny blood vessels in the kidneys responsible for filtering waste and excess fluid from the blood. This condition can lead to kidney damage and impaired kidney function.

While C3 Glomerulopathy is the commonly used term, there are several synonyms that refer to the same condition:

• Dense Deposit Disease (DDD): DDD is a subtype of C3G characterized by the presence of dense deposits of C3 in the glomeruli. These deposits can be seen under an electron microscope.


• Membranoproliferative Glomerulonephritis Type II (MPGN II): MPGN II is another term used to describe C3G. It refers to the abnormal thickening of the glomerular basement membrane, which is caused by the deposition of C3.


• Atypical Hemolytic Uremic Syndrome (aHUS): aHUS is a rare genetic disorder that can sometimes be associated with C3G. It is characterized by the formation of blood clots in small blood vessels, leading to kidney damage.


• Complement-Mediated Glomerulopathy: This term encompasses a group of kidney disorders, including C3G, that are caused by abnormalities in the complement system, which is a part of the immune system.

It is important to note that while these terms are used interchangeably, they all refer to the same underlying condition of C3 Glomerulopathy. The choice of terminology may vary depending on the specific diagnostic criteria used or the focus of research studies.