What is C3 Glomerulopathy C3G

C3 Glomerulopathy (C3G) is a rare kidney disorder characterized by abnormal deposits of a protein called C3 in the glomeruli, which are the tiny blood vessels in the kidneys responsible for filtering waste and excess fluid from the blood. These deposits can lead to inflammation and damage to the kidneys over time. C3G is a type of glomerulonephritis, a group of diseases that affect the glomeruli.

Symptoms of C3G can vary but often include blood in the urine, proteinuria (excessive protein in the urine), high blood pressure, and decreased kidney function. Some individuals may also experience swelling in the legs and ankles.

Diagnosis of C3G involves a combination of medical history evaluation, physical examination, blood tests, urine tests, and kidney biopsy. Genetic testing may also be recommended to identify any underlying genetic mutations associated with the condition.

Treatment for C3G aims to manage symptoms, slow down the progression of kidney damage, and prevent complications. This may involve medications to control blood pressure, reduce inflammation, and suppress the immune system. In some cases, kidney transplantation may be necessary.

It is important for individuals with C3G to work closely with a healthcare team specializing in kidney disorders to develop a personalized treatment plan and receive regular monitoring of kidney function.