Which are the symptoms of Castleman disease?

Castleman disease, also known as Castleman's disease or angiofollicular lymph node hyperplasia, is a rare disorder that affects the lymph nodes and related tissues. It was first described by Dr. Benjamin Castleman in the 1950s. Castleman disease can occur in two forms: unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD).

Symptoms of Castleman Disease

The symptoms of Castleman disease can vary depending on the type and location of the disease. Here are some common symptoms associated with each form:

Unicentric Castleman Disease (UCD)

In UCD, the disease is localized to a single lymph node or a group of lymph nodes in one region of the body. The symptoms of UCD are often mild and may include:

• Enlarged lymph nodes: The affected lymph nodes may be palpable and can cause discomfort or pain.


• Fever: Low-grade fever may be present.


• Night sweats: Excessive sweating during sleep can occur.


• Flu-like symptoms: Fatigue, weakness, and general malaise may be experienced.

Multicentric Castleman Disease (MCD)

MCD is characterized by the presence of multiple enlarged lymph nodes in different regions of the body. It is more aggressive than UCD and can involve various organ systems. The symptoms of MCD are often more severe and may include:

• Enlarged lymph nodes: Multiple enlarged lymph nodes, often in the neck, armpits, and groin, can be felt.


• Fever: High fever, sometimes spiking to over 102°F (39°C), is common.


• Night sweats: Profuse sweating during sleep is a frequent symptom.


• Weight loss: Unexplained weight loss may occur.


• Weakness and fatigue: Generalized weakness and fatigue can be debilitating.


• Swollen liver or spleen: In some cases, the liver or spleen may become enlarged.


• Edema: Fluid retention and swelling, particularly in the legs, can occur.


• Neuropathy: Nerve damage may lead to numbness, tingling, or weakness in the extremities.


• Autoimmune symptoms: Some individuals may experience autoimmune symptoms such as skin rashes, joint pain, or muscle weakness.


• Organ dysfunction: In severe cases, Castleman disease can affect organ function, leading to complications.

If you experience any of these symptoms, it is important to consult a healthcare professional for a proper diagnosis and appropriate management.