Cerebrocostomandibular Syndrome is an extremely rare genetic disorder characterized by a combination of craniofacial, vertebral, and rib abnormalities. Due to its rarity, the prevalence of this syndrome is not well-established. However, it is estimated to affect only a small number of individuals worldwide. The condition is typically diagnosed in infancy or early childhood, and its exact cause remains unknown. Individuals with Cerebrocostomandibular Syndrome may experience various symptoms and require multidisciplinary medical care. As research continues, further understanding of the prevalence and underlying mechanisms of this syndrome may be gained.