What is the prevalence of Cherubism?
How many people does Cherubism affect? Does it have the same prevalence in men and women? And in the different countries?
Cherubism is a rare genetic disorder characterized by abnormal bone development in the jaw and skull. It primarily affects children and is more common in males than females. The exact prevalence of Cherubism is unknown, but it is estimated to occur in approximately 1 in 200,000 to 400,000 individuals worldwide. The condition typically presents in early childhood and gradually progresses until puberty, after which it stabilizes or regresses. Cherubism is often self-limiting and does not usually cause significant functional impairment. However, it can have a significant impact on facial appearance, requiring careful management and support for affected individuals.
Cherubism is a rare genetic disorder that affects the development of the jaw and facial bones. It is characterized by abnormal growth of these bones, giving the affected individual a cherubic or angelic appearance.
The prevalence of Cherubism is estimated to be around 1 in 200,000 to 400,000 individuals worldwide. It is more commonly observed in children, typically appearing between the ages of 2 and 5. Cherubism affects both males and females equally and has been reported in various ethnic groups.
Cherubism is caused by mutations in the SH3BP2 gene, which plays a role in regulating bone development. These mutations lead to the overgrowth of bone cells in the jaw and facial areas. The severity of the condition can vary, with some individuals experiencing mild symptoms while others may have more pronounced facial deformities.
Although Cherubism is a rare condition, it is important for affected individuals to receive proper medical care and support. Treatment options may include surgery to correct facial abnormalities and orthodontic interventions to improve dental alignment. Regular monitoring and follow-up with healthcare professionals are crucial to manage the condition effectively.
