Which are the symptoms of Chronic myelogenous leukemia (CML)?

Symptoms of Chronic Myelogenous Leukemia (CML)

Chronic Myelogenous Leukemia (CML) is a type of cancer that affects the blood and bone marrow. It is characterized by the uncontrolled growth of abnormal white blood cells, known as myeloid cells. While some individuals with CML may not experience any symptoms initially, others may exhibit various signs that can indicate the presence of the disease.

1. Fatigue: One of the most common symptoms of CML is persistent fatigue or a general feeling of weakness. This fatigue can be severe and may not improve with rest or sleep.

2. Unexplained Weight Loss: Individuals with CML may experience unexplained weight loss despite maintaining their regular diet and eating habits. This weight loss can be significant and may occur over a relatively short period.

3. Abdominal Discomfort: Some individuals with CML may experience abdominal pain or discomfort. This can manifest as a dull ache or a feeling of fullness in the abdomen.

4. Enlarged Spleen: The spleen, which is responsible for filtering the blood and fighting infections, may become enlarged in individuals with CML. This can cause discomfort or pain in the left upper abdomen.

5. Night Sweats: Excessive sweating, particularly during the night, is another symptom that may be observed in individuals with CML. These night sweats can be severe and may disrupt sleep patterns.

6. Bone Pain: CML can cause bone pain, typically in the long bones such as the arms and legs. This pain may be persistent or intermittent and can be accompanied by joint pain.

7. Easy Bruising or Bleeding: CML can affect the body's ability to produce normal blood cells, including platelets responsible for clotting. As a result, individuals with CML may experience easy bruising, bleeding gums, or frequent nosebleeds.

8. Infections: CML weakens the immune system, making individuals more susceptible to infections. Recurrent or persistent infections, such as respiratory or urinary tract infections, may be indicative of CML.

9. Fever: Some individuals with CML may experience recurrent or persistent low-grade fevers without any apparent cause. These fevers may come and go or persist for an extended period.

10. Pale Skin: CML can lead to a decrease in red blood cells, resulting in anemia. Anemia can cause pale skin, weakness, and shortness of breath.

If you experience any of these symptoms or have concerns about your health, it is important to consult a healthcare professional for a proper diagnosis. Keep in mind that these symptoms can also be associated with other conditions, so a thorough evaluation is necessary to determine the underlying cause.