Which are the symptoms of Chronic Recurrent Multifocal Osteomyelitis?

Symptoms of Chronic Recurrent Multifocal Osteomyelitis

Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a rare autoinflammatory bone disorder that primarily affects children and adolescents. It is characterized by recurrent episodes of inflammation in multiple bones throughout the body. The exact cause of CRMO is still unknown, but it is believed to involve an abnormal immune response.

1. Bone Pain: The most common symptom of CRMO is persistent bone pain. The pain can be localized to a specific bone or may involve multiple bones simultaneously. The intensity of the pain can vary from mild to severe and may worsen with physical activity or at night.

2. Swelling and Tenderness: Affected bones may become swollen, tender, and warm to the touch. The swelling and tenderness are often localized to the site of inflammation and can make it difficult to move the affected limb or joint.

3. Fatigue: Many individuals with CRMO experience fatigue and a general feeling of being unwell. This can be attributed to the chronic inflammation and pain associated with the condition.

4. Fever: During active episodes of inflammation, individuals with CRMO may develop a low-grade fever. The fever is typically mild but can persist for several days or weeks.

5. Skin Changes: In some cases, CRMO may cause skin changes near the affected bones. These changes can include redness, warmth, or the formation of small nodules or abscesses.

6. Limited Range of Motion: When CRMO affects joints, it can lead to a limited range of motion. This can make it difficult to perform certain movements or activities.

7. Recurrent Episodes: CRMO is characterized by recurrent episodes of bone inflammation. These episodes can occur sporadically, with periods of remission in between. The frequency and duration of the episodes can vary widely between individuals.

8. Systemic Involvement: In some cases, CRMO can affect other organs or systems in the body. This can lead to additional symptoms such as abdominal pain, gastrointestinal issues, or skin rashes.

9. Delayed Diagnosis: Due to its rarity and the variability of symptoms, CRMO is often misdiagnosed or undiagnosed for an extended period. This can result in delays in appropriate treatment and management.

It is important to note that the symptoms of CRMO can vary significantly between individuals. Some individuals may experience mild symptoms, while others may have more severe and debilitating manifestations. If you or your child experience persistent bone pain or any of the mentioned symptoms, it is essential to consult a healthcare professional for a proper evaluation and diagnosis.