What is Cloves Syndrome

Cloves Syndrome, also known as Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, and Scoliosis/Skeletal/Spinal Anomalies and/or Syndactyly Syndrome, is a rare and complex disorder that affects various parts of the body.

Cloves Syndrome is characterized by the presence of lipomatous overgrowth (excessive fatty tissue), vascular malformations (abnormal blood vessels), epidermal nevi (skin abnormalities), and scoliosis/skeletal/spinal anomalies (abnormalities in the spine and skeletal system) along with possible syndactyly (webbing or fusion of fingers/toes).

This condition typically manifests at birth or early childhood and can lead to a range of symptoms and complications, including overgrowth of body parts, vascular abnormalities causing pain and swelling, skin abnormalities such as birthmarks or skin tags, and skeletal abnormalities affecting mobility and posture.

Diagnosis of Cloves Syndrome involves a thorough clinical evaluation, imaging tests, and genetic testing to identify any underlying genetic mutations. Treatment options are primarily focused on managing the symptoms and may include surgical interventions to address overgrowth or correct skeletal abnormalities, medications to alleviate pain and reduce vascular malformations, and physical therapy to improve mobility and function.

As Cloves Syndrome is a rare and complex disorder, it is crucial for individuals affected by it to receive comprehensive medical care and support from a multidisciplinary team of healthcare professionals.