Critical limb ischemia synonyms

Critical limb ischemia (CLI) is a severe form of peripheral arterial disease (PAD) that results in inadequate blood flow to the limbs, particularly the legs and feet. It is characterized by chronic ischemic rest pain, non-healing wounds, and tissue loss, which can eventually lead to limb amputation if left untreated. CLI is considered a medical emergency and requires immediate attention to prevent irreversible damage.

CLI is often referred to by several synonyms, which include:

• Chronic limb-threatening ischemia (CLTI): This term emphasizes the chronic nature of the condition and the potential threat it poses to limb viability.


• Advanced peripheral artery disease (PAD): CLI is an advanced stage of PAD, which is a condition that affects the blood vessels outside the heart and brain.


• Severe limb ischemia: This term highlights the severity of the blood flow restriction to the limbs.


• End-stage peripheral arterial disease: CLI is considered the end-stage of PAD, where the blood flow is severely compromised and tissue damage becomes evident.

It is crucial to recognize the symptoms of CLI, which may include persistent leg pain, non-healing wounds or ulcers, coldness or numbness in the affected limb, and weak or absent pulses. Prompt diagnosis and treatment are essential to improve outcomes and prevent limb loss.

Treatment options for CLI may include lifestyle modifications, medications to manage underlying risk factors, minimally invasive procedures such as angioplasty or stenting to restore blood flow, or surgical interventions like bypass grafting. In some cases, amputation may be necessary if the limb cannot be salvaged.

Early detection and intervention are key in managing CLI and preventing its devastating consequences. If you or someone you know experiences symptoms suggestive of CLI, it is crucial to seek medical attention promptly to receive appropriate care and prevent further complications.