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What is the history of Dermatitis Herpetiformis?

When was Dermatitis Herpetiformis discovered? What is the story of this discovery? Was it coincidence or not?

History of Dermatitis Herpetiformis

Dermatitis Herpetiformis (DH) is a chronic autoimmune skin condition characterized by intensely itchy and blistering skin lesions. It is closely associated with celiac disease, an autoimmune disorder triggered by gluten consumption. DH was first described in the late 19th century by dermatologist Louis Duhring, who initially named it "dermatitis herpetiformis multiformis."



The term "dermatitis herpetiformis" refers to the appearance of the skin lesions, which resemble those caused by herpes infections. However, it is important to note that DH is not caused by the herpes virus.



The link between DH and celiac disease was established in the 1960s when researchers discovered the presence of gluten-specific antibodies in the skin of DH patients. These antibodies, known as IgA antibodies, are also found in the small intestine of individuals with celiac disease.



The underlying cause of DH is an abnormal immune response to gluten. When individuals with DH consume gluten-containing foods, such as wheat, barley, and rye, their immune system reacts by producing IgA antibodies. These antibodies then accumulate in the small blood vessels of the skin, leading to inflammation and the characteristic skin lesions.



Over the years, researchers have made significant advancements in understanding the pathophysiology of DH. In the 1990s, the protein responsible for triggering the immune response in DH was identified as tissue transglutaminase (tTG). Tissue transglutaminase is an enzyme involved in the breakdown of gluten in the intestine. In individuals with DH, tTG becomes abnormally active and triggers the production of IgA antibodies.



Diagnosing DH typically involves a combination of clinical evaluation, skin biopsy, and blood tests. Skin biopsy is performed to examine the presence of IgA deposits in the skin, while blood tests can detect the presence of IgA antibodies and other celiac disease-related markers.



Treatment for DH primarily involves a strict gluten-free diet. By eliminating gluten from their diet, individuals with DH can effectively manage their symptoms and prevent further skin lesions. In some cases, medications such as dapsone may be prescribed to alleviate itching and reduce inflammation.



It is worth noting that DH is a lifelong condition, and adherence to a gluten-free diet is essential to prevent symptom recurrence and long-term complications. With proper management, individuals with DH can lead healthy and fulfilling lives.



In conclusion, Dermatitis Herpetiformis is a chronic autoimmune skin condition closely associated with celiac disease. It was first described in the late 19th century and is characterized by intensely itchy and blistering skin lesions. The underlying cause of DH is an abnormal immune response to gluten, specifically triggered by tissue transglutaminase. Diagnosis involves clinical evaluation, skin biopsy, and blood tests. Treatment primarily involves a strict gluten-free diet, and adherence to this diet is crucial for long-term management.


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History of Dermatitis Herpetiformis

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DERMATITIS HERPETIFORMIS STORIES
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after years taking dapsone for DH I did a fructose and histamine intolerance test, and when I did a diet of both plus gluten then the DH disappear
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has anyone tried apoquel to allieviat symptoms?

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