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What are the best treatments for Devic Syndrome / NMO?

See the best treatments for Devic Syndrome / NMO here

Devic Syndrome / NMO treatments

Treatments for Devic Syndrome / NMO


Devic Syndrome, also known as Neuromyelitis Optica (NMO), is a rare autoimmune disorder that primarily affects the optic nerves and spinal cord. It is characterized by recurrent episodes of optic neuritis (inflammation of the optic nerve) and transverse myelitis (inflammation of the spinal cord). The condition can cause significant disability and impact the quality of life for those affected. While there is no cure for Devic Syndrome, there are several treatment options available to manage the symptoms and prevent relapses.



Immunosuppressive Therapy


Immunosuppressive therapy is a cornerstone of treatment for Devic Syndrome. The goal is to suppress the immune system to reduce the frequency and severity of attacks. Medications such as azathioprine, mycophenolate mofetil, and methotrexate are commonly used to achieve this. These drugs work by dampening the immune response and preventing the immune system from attacking the optic nerves and spinal cord. Regular monitoring of blood counts and liver function is necessary while on immunosuppressive therapy.



High-Dose Corticosteroids


High-dose corticosteroids are often prescribed during acute attacks to reduce inflammation and speed up recovery. Intravenous methylprednisolone is the most commonly used corticosteroid in this context. It is usually administered for a few days, followed by a gradual tapering of the dose. Corticosteroids can help alleviate symptoms and prevent further damage to the optic nerves and spinal cord. However, long-term use of high-dose corticosteroids is generally not recommended due to their potential side effects.



Plasma Exchange (Plasmapheresis)


Plasma exchange, also known as plasmapheresis, is a procedure that involves removing the patient's blood plasma and replacing it with a substitute solution. This treatment is used in severe cases or when there is a poor response to corticosteroids. Plasma exchange helps remove harmful antibodies and inflammatory mediators from the bloodstream, reducing the severity and duration of attacks. It can be an effective option for acute management of Devic Syndrome.



Monoclonal Antibodies


Monoclonal antibodies are a newer class of medications that target specific components of the immune system involved in the development of Devic Syndrome. One such monoclonal antibody is called rituximab. It works by depleting B cells, which play a role in the autoimmune response. Rituximab has shown promising results in reducing relapse rates and improving overall outcomes in patients with Devic Syndrome. However, further research is needed to establish its long-term safety and efficacy.



Supportive Care


In addition to specific treatments, supportive care plays a crucial role in managing Devic Syndrome. This includes regular monitoring of visual function, mobility, and overall neurological status. Rehabilitation therapies, such as physical therapy and occupational therapy, can help improve muscle strength, coordination, and daily functioning. Assistive devices, such as walking aids or visual aids, may be recommended to enhance independence and quality of life.



Preventive Measures


Preventing relapses is a key aspect of managing Devic Syndrome. Preventive measures may include long-term immunosuppressive therapy, as mentioned earlier, to reduce the frequency and severity of attacks. Additionally, avoiding triggers that may worsen symptoms, such as infections or excessive heat exposure, is important. Regular follow-up with a neurologist or specialist experienced in treating Devic Syndrome is essential to monitor disease activity and adjust treatment plans accordingly.



It is important to note that the treatment approach for Devic Syndrome may vary depending on the individual's specific symptoms, disease severity, and response to different therapies. Therefore, it is crucial to consult with a healthcare professional for personalized medical advice and guidance.


Diseasemaps
4 answers
Chemo therapy / retuxamab

Posted Sep 27, 2017 by Erica Pretty 600
Retuximab has been a wonderful drug and kept my disease at bay for 3 years with only mild relapses

Posted Jun 8, 2018 by Tash 3050
Intially cortico steroids and immuno suppressants

Posted Jul 6, 2018 by Ravi 1500

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Woke up one morning with fuzzy vision, eventually found out I was blind in one eye and steadily losing vision in the other.  After numerous test was diagnosed with NMO.  Have learned how to live with low vision in the only eye I have left and have ...

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