Which are the causes of Dysautonomia / POTS?

Dysautonomia, including Postural Orthostatic Tachycardia Syndrome (POTS), is a complex disorder that affects the autonomic nervous system (ANS). The ANS is responsible for regulating various bodily functions, such as heart rate, blood pressure, digestion, and temperature control. When the ANS malfunctions, it can lead to a wide range of symptoms and conditions, including dysautonomia and POTS.

While the exact causes of dysautonomia and POTS are not fully understood, there are several factors that are believed to contribute to their development:

1. Genetic Factors: Research suggests that there may be a genetic predisposition to dysautonomia and POTS. Certain gene mutations or variations may affect the functioning of the autonomic nervous system, making individuals more susceptible to developing these conditions.



2. Autoimmune Disorders: Some cases of dysautonomia and POTS have been associated with autoimmune disorders, where the immune system mistakenly attacks the body's own tissues. Autoimmune conditions such as lupus, Sjögren's syndrome, and rheumatoid arthritis have been linked to dysautonomia and POTS.



3. Physical Trauma: In some cases, dysautonomia and POTS can develop following physical trauma, such as a head injury or surgery. The trauma may disrupt the normal functioning of the autonomic nervous system, leading to the onset of symptoms.



4. Infections: Certain viral or bacterial infections have been associated with the development of dysautonomia and POTS. Infections like Epstein-Barr virus (EBV), Lyme disease, and viral gastroenteritis have been linked to autonomic dysfunction. It is believed that these infections trigger an immune response that affects the autonomic nervous system.



5. Hormonal Imbalances: Hormones play a crucial role in regulating various bodily functions, including those controlled by the autonomic nervous system. Fluctuations or imbalances in hormone levels, such as estrogen or thyroid hormones, may contribute to the development of dysautonomia and POTS.



6. Chronic Stress: Prolonged periods of stress can have a significant impact on the autonomic nervous system. Chronic stress may disrupt the balance of neurotransmitters and hormones involved in ANS regulation, potentially leading to dysautonomia and POTS.



7. Other Medical Conditions: Certain medical conditions, such as Ehlers-Danlos syndrome, Chiari malformation, and mast cell activation syndrome, have been associated with dysautonomia and POTS. These conditions may directly affect the autonomic nervous system or contribute to its dysfunction.

It is important to note that dysautonomia and POTS can have a multifactorial etiology, meaning that multiple factors may interact and contribute to their development. Additionally, while these potential causes have been identified, further research is needed to fully understand the underlying mechanisms and relationships between these factors and the onset of dysautonomia and POTS.