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Which are the causes of Eisenmenger Syndrome?

See some of the causes of Eisenmenger Syndrome according to people who have experience in Eisenmenger Syndrome

Eisenmenger Syndrome causes

Eisenmenger Syndrome is a rare and serious condition that develops as a result of certain congenital heart defects. It is characterized by the reversal or shunting of blood flow within the heart, leading to increased pressure in the pulmonary arteries. This increased pressure causes the blood vessels in the lungs to become thickened and narrowed, ultimately leading to irreversible damage.

The primary cause of Eisenmenger Syndrome is a congenital heart defect known as a left-to-right shunt. This means that there is an abnormal connection between the systemic circulation (carrying oxygenated blood) and the pulmonary circulation (carrying deoxygenated blood). The most common congenital heart defects associated with Eisenmenger Syndrome include ventricular septal defect (VSD), atrial septal defect (ASD), and patent ductus arteriosus (PDA).

In individuals with these defects, blood flows from the left side of the heart (which has higher pressure) to the right side of the heart (which has lower pressure). Over time, this increased blood flow to the lungs causes the pulmonary arteries to become thickened and narrowed. As a result, the pressure in the pulmonary arteries rises, eventually surpassing the pressure in the systemic circulation.

The increased pressure in the pulmonary arteries triggers a process called pulmonary vascular remodeling. This involves the proliferation of smooth muscle cells and the deposition of collagen and other proteins, leading to the thickening and narrowing of the blood vessels. As the pulmonary arteries become more obstructed, blood flow is redirected through alternative pathways, known as right-to-left shunting.

The reversal of blood flow from right to left bypasses the lungs, resulting in systemic circulation of deoxygenated blood. This leads to a decrease in oxygen levels in the systemic circulation, causing a range of symptoms such as cyanosis (bluish discoloration of the skin), shortness of breath, fatigue, and exercise intolerance.

It is important to note that Eisenmenger Syndrome typically develops gradually over time, often taking years or even decades to manifest. The exact reasons why some individuals with congenital heart defects develop Eisenmenger Syndrome while others do not are not fully understood. However, factors such as the size and location of the defect, as well as the presence of additional cardiac abnormalities, may influence the development and progression of the syndrome.

In conclusion, Eisenmenger Syndrome is primarily caused by congenital heart defects that result in left-to-right shunting of blood. The increased blood flow to the lungs leads to pulmonary vascular remodeling and subsequent pulmonary hypertension. Over time, the increased pressure in the pulmonary arteries causes a reversal of blood flow, resulting in systemic circulation of deoxygenated blood. Early detection and appropriate management of congenital heart defects are crucial in preventing the development of Eisenmenger Syndrome.
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