Which are the causes of Elastofibroma Dorsi?

Elastofibroma dorsi is a rare benign soft tissue tumor that typically occurs in the subscapular region of the back, between the lower scapula and the thoracic wall. It is characterized by the development of fibrous and elastic tissue, resulting in the formation of a firm, rubbery mass. Although the exact cause of elastofibroma dorsi is not fully understood, several factors have been suggested to contribute to its development.

Genetic predisposition: Some studies have indicated a possible genetic predisposition to elastofibroma dorsi. It has been observed that the condition tends to run in families, suggesting a hereditary component. However, the specific genes involved in the development of elastofibroma dorsi have not been identified.

Repetitive microtrauma: Repetitive microtrauma or chronic mechanical stress has been proposed as a potential cause of elastofibroma dorsi. This theory suggests that the repeated friction or compression between the scapula and the thoracic wall may lead to the development of the tumor. This hypothesis is supported by the fact that elastofibroma dorsi is more commonly found in individuals who engage in activities that involve repetitive shoulder movements, such as athletes or manual laborers.

Aging: Elastofibroma dorsi is predominantly seen in older individuals, with a peak incidence between the ages of 50 and 70. This suggests that age-related changes in the connective tissue may contribute to the development of the tumor. As people age, the elasticity and resilience of the connective tissue decrease, making it more susceptible to the formation of fibrous and elastic masses.

Hormonal factors: Hormonal factors have also been proposed as a potential cause of elastofibroma dorsi. It has been observed that the tumor occurs more frequently in women than in men, with a female-to-male ratio of approximately 2:1. This gender difference suggests that hormonal influences, such as estrogen, may play a role in the development of the tumor. However, further research is needed to fully understand the hormonal mechanisms involved.

Other factors: Other factors that have been suggested to contribute to the development of elastofibroma dorsi include chronic inflammation, metabolic disorders, and genetic mutations. However, the exact role of these factors in the pathogenesis of the tumor remains unclear and requires further investigation.

In conclusion, while the exact cause of elastofibroma dorsi is not fully understood, genetic predisposition, repetitive microtrauma, aging, hormonal factors, and other potential factors may contribute to its development. Further research is needed to unravel the complex mechanisms underlying this rare soft tissue tumor.