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Is Factor XIII Deficiency hereditary?

Here you can see if Factor XIII Deficiency can be hereditary. Do you have any genetic components? Does any member of your family have Factor XIII Deficiency or may be more predisposed to developing the condition?

Is Factor XIII Deficiency hereditary?

Yes, Factor XIII Deficiency is hereditary. It is a rare genetic disorder that is passed down from parents to their children. It is caused by mutations in the F13A1 or F13B gene, which affects the production or function of Factor XIII, a blood clotting protein. Individuals with Factor XIII Deficiency have a higher risk of bleeding and may experience symptoms such as easy bruising, prolonged bleeding, and delayed wound healing.



Factor XIII Deficiency is a rare inherited bleeding disorder that affects the blood's ability to clot properly. It is caused by a deficiency or dysfunction of a protein called Factor XIII, which plays a crucial role in the final stages of blood clot formation.


Yes, Factor XIII Deficiency is hereditary. It is passed down from parents to their children through genetic mutations. The condition follows an autosomal recessive pattern of inheritance, meaning that both parents must carry a copy of the mutated gene for their child to be affected.


When both parents are carriers of the mutated gene, there is a 25% chance with each pregnancy that their child will inherit two copies of the mutated gene and develop Factor XIII Deficiency. Individuals who inherit only one copy of the mutated gene are considered carriers and typically do not experience any symptoms of the disorder.


It is important for individuals with a family history of Factor XIII Deficiency to undergo genetic testing and counseling. This can help determine their risk of passing the condition to their children and provide information on potential treatment options and preventive measures.


While Factor XIII Deficiency is a hereditary condition, it is important to note that not all individuals with a family history of the disorder will develop symptoms. Factors such as the severity of the mutation and other genetic and environmental factors can influence the expression of the disorder.


Early diagnosis and appropriate management are crucial in preventing complications associated with Factor XIII Deficiency. Therefore, individuals with a family history of the disorder should consult with a healthcare professional for proper evaluation and guidance.


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