What is Factor XIII Deficiency

Factor XIII Deficiency is a rare inherited bleeding disorder that affects the blood's ability to clot properly. It is caused by a deficiency or dysfunction of Factor XIII, a clotting protein in the blood. Factor XIII plays a crucial role in stabilizing blood clots, preventing their breakdown and promoting wound healing.

Individuals with Factor XIII Deficiency may experience prolonged bleeding after injuries, surgeries, or dental procedures. They may also have spontaneous bleeding into joints and muscles, leading to pain and swelling. Women with this condition may have heavy or prolonged menstrual bleeding.

Factor XIII Deficiency is typically diagnosed through blood tests that measure the levels and activity of Factor XIII. Treatment involves replacing the missing or defective Factor XIII through infusions of concentrated Factor XIII concentrates. This can help prevent bleeding episodes and improve overall quality of life.

While Factor XIII Deficiency is a lifelong condition, with proper management and treatment, individuals with this disorder can lead normal and active lives.