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Which are the causes of Fibrous Dysplasia?

See some of the causes of Fibrous Dysplasia according to people who have experience in Fibrous Dysplasia

Fibrous Dysplasia causes

Fibrous dysplasia is a rare bone disorder that primarily affects the development and growth of bone tissue. It is characterized by the abnormal replacement of normal bone with fibrous tissue, leading to weakened and deformed bones. The exact cause of fibrous dysplasia is not yet fully understood, but several factors have been identified as potential contributors to the development of this condition.



Genetic Mutations


One of the primary causes of fibrous dysplasia is genetic mutations. These mutations occur in a gene known as GNAS1, which is responsible for producing a protein called Gs alpha. Gs alpha plays a crucial role in regulating the activity of certain enzymes involved in bone formation and remodeling. When mutations occur in the GNAS1 gene, it can lead to the overactivation of these enzymes, disrupting the normal bone development process and resulting in fibrous dysplasia.



Somatic Mosaicism


Fibrous dysplasia often arises from somatic mosaicism, a phenomenon where genetic mutations occur in some cells of the body but not in others. This means that individuals with fibrous dysplasia typically have a mixture of normal and mutated cells within their affected bones. The presence of somatic mosaicism can explain why fibrous dysplasia is often localized to specific bones or regions of the body.



Hormonal Imbalances


Hormonal imbalances have also been implicated in the development of fibrous dysplasia. Studies have shown that increased levels of certain hormones, such as estrogen, can contribute to the progression and severity of the condition. Estrogen is known to stimulate the activity of the Gs alpha protein, which, when mutated, can exacerbate the abnormal bone growth seen in fibrous dysplasia.



Unknown Triggers


While genetic mutations and hormonal imbalances play significant roles in the development of fibrous dysplasia, there are cases where the exact triggers remain unknown. It is possible that other genetic or environmental factors may contribute to the onset of the condition. Further research is needed to uncover these potential triggers and gain a more comprehensive understanding of fibrous dysplasia.



Conclusion


In summary, fibrous dysplasia is primarily caused by genetic mutations in the GNAS1 gene, leading to the overactivation of enzymes involved in bone formation and remodeling. Somatic mosaicism, hormonal imbalances, and potentially other unknown triggers also contribute to the development of this rare bone disorder. Understanding the underlying causes of fibrous dysplasia is crucial for developing effective treatments and interventions to improve the quality of life for individuals affected by this condition.


Diseasemaps
7 answers
What Is the Cause?
Fibrous dysplasia is caused by a defective gene in the cells that form bone and other affected tissues. The defect occurs at some point after conception, most likely early in fetal development. This means that the disorder is not inherited from an affected person’s parents, nor can an affected person with the condition pass it on to his or her children.

Posted Jun 9, 2017 by Lisa Hill 2050
Genetic disorder. Not known

Posted Jul 21, 2017 by Debra 2000
A chromosomal mutation occurring while a fetus. Not heredity.

Posted Sep 9, 2017 by Debby 1200
There are no known causes of how people get fibrous dysplasia

Posted Oct 7, 2017 by Kiesha brown 3050
It was based on mutations, thankfully not hereditary but still a genetic disease. It happened before birth so you cannot exactly stop or cure it.

Posted Oct 23, 2020 by anna_d09 2500
It happens at conception, your parents didn’t pass it onto you, and you can’t pass it to your kids.

Posted Jan 17, 2021 by Emmy 2250

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FIBROUS DYSPLASIA STORIES
Fibrous Dysplasia stories
HELLO, MY NAME IS MICHELLE, i AM 37, MY BODY HAS A LONG LIST OF UNIQUE AILMENTS. i BELIEVE MANY STEM FROM MY HAVING mCcUNE ALBRIGHT SYNDROME. i ALSO HAVE  FIBROUS DYSPLASIA IN MANY BONES IN MY SKUL AND SUSPECT IN MY ANKLE AND SOME RIBS, i HAVE SCOLI...
Fibrous Dysplasia stories
I was diagnosed when I was in the 6th grade.  It was my birthday when they did the x-ray.  They sent me to the Oncologist to confirm it was FD and not cancer.  I have FD in my Left Tibia.  As of now, I have had 11 surgeries outpatient and inpatie...
Fibrous Dysplasia stories
After suffering with chronic pain for almost 2 years I finally got a diagnosis of Fibrous Dysplasia of the skull. I have a very large lesion in the back of head that goes all the way across the occipital bone. Doctor explained that it wraps around my...
Fibrous Dysplasia stories
Hi all. I've joined this map but it's my son who has PFD. Found out when his leg broke at age 8. Long hard struggle ever since but knowing we're not alone has made it easier. Daniel is soon 12 & struggling at secondary school but has some fab friends...
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Fibrous Dysplasia forum

FIBROUS DYSPLASIA FORUM
Fibrous Dysplasia forum
I was wondering if there was a spot to clarify the type of FD we have.  There is monostotic, polyostotic and McCune-Albright syndrome with polyostotic (which i have) ?  I did not see McCune-Albright syndrome on the list. 

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