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What is the prevalence of Food Protein-Induced Enterocolitis Syndrome?

How many people does Food Protein-Induced Enterocolitis Syndrome affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Food Protein-Induced Enterocolitis Syndrome

Food Protein-Induced Enterocolitis Syndrome (FPIES) is a relatively rare non-IgE mediated gastrointestinal food allergy that primarily affects infants and young children. The exact prevalence of FPIES is not well-established, but it is estimated to affect approximately 0.34% to 0.5% of infants and young children. FPIES is characterized by delayed onset vomiting, diarrhea, and sometimes failure to thrive. It is often triggered by common food proteins such as cow's milk, soy, and grains. Diagnosis and management of FPIES require medical evaluation and dietary modifications under the guidance of healthcare professionals.



Food Protein-Induced Enterocolitis Syndrome (FPIES) is a relatively rare but potentially severe non-IgE mediated gastrointestinal food allergy. It primarily affects infants and young children, with symptoms typically appearing within the first few months of life. FPIES is characterized by repetitive episodes of profuse vomiting, diarrhea, and dehydration, often occurring a few hours after ingesting certain trigger foods.



The prevalence of FPIES varies across different populations and regions. While exact figures are challenging to determine due to underdiagnosis and misdiagnosis, studies suggest that FPIES affects approximately 0.34% to 0.5% of infants and young children. However, it is important to note that these numbers may not fully represent the true prevalence, as many cases go undiagnosed or are misclassified as other conditions.



Given the potential severity of FPIES reactions and the impact on affected individuals and their families, it is crucial for healthcare professionals to be aware of this condition and consider it in the differential diagnosis of infants and children presenting with symptoms consistent with FPIES.


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