What is Glucose-Galactose Malabsorption

Glucose-Galactose Malabsorption (GGM) is a rare genetic disorder that affects the absorption of glucose and galactose in the small intestine. It is characterized by a deficiency or dysfunction of the SGLT1 protein, which is responsible for transporting glucose and galactose from the intestine into the bloodstream.

Individuals with GGM are unable to properly absorb glucose and galactose, leading to digestive symptoms such as diarrhea, abdominal pain, and bloating after consuming foods containing these sugars. This malabsorption can result in malnutrition and dehydration if not managed properly.

The condition is typically diagnosed in infancy or early childhood when symptoms become apparent after introducing foods containing glucose and galactose, such as breast milk or formula. Genetic testing can confirm the diagnosis.

Treatment for GGM involves strict avoidance of foods containing glucose and galactose. Infants may require specialized formulas that are low in these sugars. With proper management and dietary modifications, individuals with GGM can lead healthy lives.