Gorlin-Chaudhry-Moss Syndrome synonyms

Gorlin-Chaudhry-Moss Syndrome, also known as GCM syndrome, is a rare genetic disorder characterized by a combination of craniofacial, skeletal, and cardiovascular abnormalities. It was first described by Gorlin, Chaudhry, and Moss in 1960.

Synonyms

Gorlin-Chaudhry-Moss Syndrome is also referred to by several other names:

• Craniofacial Dysostosis with Polysyndactyly


• Gorlin-Chaudhry Syndrome


• Gorlin-Chaudhry-Moss Craniosynostosis Syndrome


• Gorlin-Chaudhry-Moss Craniofacial Dysostosis Syndrome


• Gorlin-Chaudhry-Moss Syndrome with Craniosynostosis

Characteristics and Symptoms

GCM syndrome is characterized by distinct facial features, including a prominent forehead, wide-set eyes, down-slanting eyelid openings, a small nose with anteverted nostrils, and a small mouth with dental abnormalities. Individuals with GCM syndrome may also have craniosynostosis, which is the premature fusion of the skull bones.

Other skeletal abnormalities associated with GCM syndrome include extra fingers or toes (polydactyly), fusion of certain bones in the hands and feet (syndactyly), and short stature. Additionally, individuals with GCM syndrome may have heart defects, such as atrial septal defects or ventricular septal defects.

Treatment and Management

As GCM syndrome is a genetic disorder, there is no cure. Treatment focuses on managing the symptoms and associated health issues. This may involve surgical interventions to correct craniosynostosis, polydactyly, or other skeletal abnormalities. Regular monitoring by a multidisciplinary medical team is essential to address the individual's specific needs and provide appropriate care.

Prognosis

The prognosis for individuals with GCM syndrome varies depending on the severity of the symptoms and associated complications. Early diagnosis and intervention can improve outcomes and quality of life. However, the long-term outlook may be influenced by the presence of heart defects and other potential health issues.

Conclusion

Gorlin-Chaudhry-Moss Syndrome, also known as GCM syndrome, is a rare genetic disorder characterized by craniofacial, skeletal, and cardiovascular abnormalities. It is also referred to by several synonyms, including Craniofacial Dysostosis with Polysyndactyly and Gorlin-Chaudhry Syndrome. Treatment focuses on managing symptoms and associated health issues, while the prognosis varies depending on the severity of the condition. Early diagnosis and intervention play a crucial role in improving outcomes for individuals with GCM syndrome.