Is Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) hereditary?
Here you can see if Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) can be hereditary. Do you have any genetic components? Does any member of your family have Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) or may be more predisposed to developing the condition?
Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) is indeed hereditary. It is an autosomal recessive disorder caused by mutations in the mevalonate kinase (MVK) gene. This gene is responsible for producing an enzyme involved in the biosynthesis of cholesterol. Individuals with HIDS inherit two copies of the mutated gene, one from each parent. The condition is characterized by recurrent fevers, abdominal pain, joint pain, and other symptoms. Genetic counseling is recommended for families with a history of HIDS to understand the risk of passing on the condition.
Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) is a rare genetic disorder that is characterized by recurrent episodes of fever accompanied by various symptoms such as abdominal pain, joint pain, skin rashes, and swollen lymph nodes. It is caused by mutations in the mevalonate kinase (MVK) gene, which is inherited in an autosomal recessive manner.
Autosomal recessive inheritance means that an individual must inherit two copies of the mutated gene, one from each parent, in order to develop the condition. If both parents are carriers of the mutated gene, there is a 25% chance with each pregnancy that their child will inherit two copies of the gene and be affected by HIDS.
It is important to note that being a carrier of the mutated MVK gene does not typically cause any symptoms or health problems. Carriers have one normal copy of the gene and one mutated copy, and they can pass either copy to their children. If only one parent is a carrier, the child will not develop HIDS but will have a 50% chance of being a carrier themselves.
Genetic testing can be performed to determine if an individual carries the mutated MVK gene and is at risk of passing it on to their children. This information can be valuable for family planning and making informed decisions about having children.
In conclusion, Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) is a hereditary condition caused by mutations in the MVK gene. It is inherited in an autosomal recessive manner, meaning that both parents must be carriers of the mutated gene for their child to be affected. Genetic testing can provide valuable information for individuals and couples who are planning to have children.
