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How do I know if I have Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS)?

What signs or symptoms may make you suspect you may have Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS). People who have experience in Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) offer advice of what things may make you suspicious and which doctor you should go to to receive treatment

Do I have Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS)?

Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS) is a rare genetic disorder characterized by recurrent episodes of fever accompanied by various symptoms. It is important to note that only a healthcare professional can provide an accurate diagnosis, so if you suspect you may have HIDS, it is crucial to consult with a medical expert.



The most prominent symptom of HIDS is recurrent fever, typically lasting 3-7 days and recurring every 4-6 weeks. These febrile episodes often begin during infancy or early childhood and may be accompanied by other symptoms such as:




  • Abdominal pain: Individuals with HIDS may experience abdominal discomfort, which can range from mild to severe.

  • Joint pain and swelling: Joint inflammation and swelling, particularly affecting the large joints like knees, hips, and ankles, are common during fever episodes.

  • Rash: Skin manifestations, such as a non-itchy red rash, may occur during or after febrile episodes.

  • Enlarged lymph nodes: Swollen lymph nodes, especially in the neck and groin areas, can be observed during fever episodes.

  • Headache: Some individuals may experience headaches or migraines during fever episodes.

  • Fatigue: Feeling tired or exhausted is a common symptom that may persist between fever episodes.



It is important to keep in mind that these symptoms can vary in severity and may not always be present during every fever episode. Additionally, individuals with HIDS may also experience other less common symptoms, such as sore throat, diarrhea, vomiting, or chest pain.



If you suspect you may have HIDS based on your symptoms, it is crucial to consult with a healthcare professional who can perform a thorough evaluation. Diagnosis of HIDS involves genetic testing to identify mutations in the MVK gene, which is responsible for the condition. Additionally, blood tests may be conducted to measure the levels of immunoglobulin D (IgD) and other inflammatory markers.



Remember, only a healthcare professional can provide an accurate diagnosis and appropriate treatment plan. If you are experiencing recurrent fevers or any concerning symptoms, it is recommended to seek medical attention promptly.


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