Hyperkalemic periodic paralysis synonyms

Hyperkalemic periodic paralysis is a rare genetic disorder characterized by episodes of muscle weakness or paralysis. It is also known by several other names, including:

• Hyperkalemic periodic paresis


• Hyperkalemic paralysis


• HyperPP


• Hyperkalemic myopathy


• HyperPP syndrome

These terms are often used interchangeably to describe the same condition.

Hyperkalemic periodic paralysis is caused by mutations in the SCN4A gene, which is responsible for producing a protein called the sodium channel alpha subunit. This protein plays a crucial role in controlling the movement of sodium ions in muscle cells. Mutations in the SCN4A gene disrupt the normal functioning of this protein, leading to episodes of muscle weakness or paralysis.

The symptoms of hyperkalemic periodic paralysis typically manifest during childhood or adolescence. The episodes of muscle weakness or paralysis can be triggered by various factors, including stress, exercise, cold temperatures, or a high-potassium diet.

During an episode, individuals may experience muscle stiffness, cramps, or a feeling of heaviness in the affected muscles. The weakness or paralysis can last from a few minutes to several hours. In some cases, the muscles may become so weak that individuals are unable to move at all.

Management of hyperkalemic periodic paralysis involves avoiding triggers, such as stress or high-potassium foods, and taking medications to prevent or shorten episodes. Potassium supplements are often prescribed to help regulate potassium levels in the blood. Genetic counseling may also be recommended for individuals with a family history of the condition.

Hyperkalemic periodic paralysis is a challenging condition that can significantly impact an individual's quality of life. However, with proper management and support, individuals with this disorder can lead fulfilling lives.