Insulinoma, also known as pancreatic insulinoma, is a rare neuroendocrine tumor that arises from the insulin-producing cells of the pancreas called beta cells. It is a benign tumor, meaning it is non-cancerous, and typically occurs in the pancreatic islets or islets of Langerhans. Insulinomas are usually solitary and small in size, measuring less than 2 cm in diameter.
The primary characteristic of an insulinoma is its ability to produce excessive amounts of insulin, a hormone responsible for regulating blood sugar levels. This overproduction of insulin leads to a condition called hyperinsulinemia, which results in hypoglycemia (low blood sugar levels). The symptoms of insulinoma are primarily related to hypoglycemia and may include confusion, dizziness, weakness, sweating, and palpitations. These symptoms often improve after eating or consuming something sugary.
Diagnosing insulinoma can be challenging due to its rarity and nonspecific symptoms. Various tests are used to confirm the presence of an insulinoma, including fasting blood glucose and insulin levels, proinsulin levels, C-peptide levels, and glucose tolerance tests. Imaging techniques such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) may also be employed to locate the tumor within the pancreas.
Treatment for insulinoma typically involves surgical removal of the tumor. The goal of surgery is to completely remove the tumor while preserving the healthy pancreatic tissue. In cases where the tumor cannot be surgically removed or if it has spread to other parts of the body, alternative treatments such as medical therapy or radiofrequency ablation may be considered.
In conclusion, insulinoma is a rare benign tumor of the pancreas that causes excessive production of insulin, leading to hypoglycemia. Prompt diagnosis and appropriate treatment are crucial in managing this condition and alleviating the associated symptoms.