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What is the prevalence of Isaac syndrome?

How many people does Isaac syndrome affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Isaac syndrome

The prevalence of Isaac syndrome, also known as neuromyotonia, is relatively rare. It is estimated to affect approximately 1 in 100,000 individuals worldwide. This neurological disorder is characterized by muscle stiffness, cramps, and continuous muscle fiber activity. The condition is often associated with autoimmune disorders, such as myasthenia gravis or thymoma. Diagnosis can be challenging due to its rarity and similarity to other neuromuscular conditions. Treatment options include immunosuppressive therapy, plasma exchange, and symptomatic management. Early detection and proper management can significantly improve the quality of life for individuals with Isaac syndrome.



Isaac syndrome, also known as Isaac's syndrome or neuromyotonia, is a rare neurological disorder characterized by persistent muscle stiffness, cramping, and continuous muscle twitching (myokymia). It is named after Sir William Isaac, the British physician who first described the condition in 1961.



The prevalence of Isaac syndrome is quite low, making it a rare disorder. Exact figures regarding its occurrence are challenging to determine due to its rarity and underdiagnosis. However, studies suggest that the prevalence of Isaac syndrome is estimated to be around 1 in 100,000 individuals.



Isaac syndrome is considered an autoimmune disorder, where the body's immune system mistakenly attacks the peripheral nerves, leading to abnormal nerve excitability. The condition can occur at any age, but it is most commonly diagnosed in adults between the ages of 15 and 60.



While Isaac syndrome is rare, it can significantly impact an individual's quality of life. The symptoms can vary in severity, ranging from mild muscle stiffness to more debilitating muscle cramps and spasms. Treatment options include medications to suppress the abnormal nerve activity, physical therapy, and in some cases, immunotherapy.


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Prevalence of Isaac syndrome

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