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What is the prevalence of Isotretinoin Syndrome?

How many people does Isotretinoin Syndrome affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Isotretinoin Syndrome

The prevalence of Isotretinoin Syndrome is relatively low. Isotretinoin, a medication used to treat severe acne, has been associated with a range of potential side effects, including Isotretinoin Syndrome. However, it is important to note that Isotretinoin Syndrome is considered a rare condition. While the exact prevalence is not well-established, studies suggest that it occurs in a small percentage of individuals who take isotretinoin. It is crucial for patients to be aware of the potential risks and discuss them with their healthcare provider before starting isotretinoin treatment.



Isotretinoin Syndrome is a rare condition that occurs as a result of exposure to the medication isotretinoin, commonly used to treat severe acne. The syndrome is characterized by a range of physical and developmental abnormalities in infants born to mothers who took isotretinoin during pregnancy.


While the exact prevalence of Isotretinoin Syndrome is difficult to determine, studies suggest that it affects a small percentage of infants exposed to the medication in utero. The prevalence is estimated to be around 0.2% to 0.7% of pregnancies where isotretinoin was used. However, it is important to note that these figures may vary depending on the population studied and other factors.


Isotretinoin Syndrome can lead to various birth defects, including craniofacial abnormalities, cardiovascular malformations, central nervous system abnormalities, and limb defects. Due to the potential risks associated with isotretinoin use during pregnancy, it is crucial for healthcare professionals to educate patients about the importance of contraception while taking the medication and to closely monitor women of childbearing age.


If you have concerns about isotretinoin or its potential effects, it is essential to consult with a healthcare provider who can provide personalized information and guidance.


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