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Which are the causes of Legg-Calvé-Perthes disease?

See some of the causes of Legg-Calvé-Perthes disease according to people who have experience in Legg-Calvé-Perthes disease

Legg-Calvé-Perthes disease causes

Legg-Calvé-Perthes disease, also known as Perthes disease or avascular necrosis of the femoral head, is a childhood condition that affects the hip joint. It is characterized by the temporary loss of blood supply to the femoral head (the rounded end of the thigh bone that fits into the hip socket), leading to its gradual deterioration and deformation. This condition primarily affects children between the ages of 4 and 10, with boys being more commonly affected than girls.



The exact cause of Legg-Calvé-Perthes disease is still not fully understood. However, several factors are believed to contribute to its development:




  1. Impaired blood supply: The primary factor in Legg-Calvé-Perthes disease is the disruption of blood flow to the femoral head. Without an adequate blood supply, the bone tissue gradually weakens and dies, leading to its collapse and deformation. The exact reason behind the impaired blood supply is unknown, but it is thought to be a combination of genetic and environmental factors.


  2. Genetic predisposition: There is evidence to suggest that certain genetic factors may increase the risk of developing Legg-Calvé-Perthes disease. Studies have shown that children with a family history of the condition are more likely to develop it themselves. However, the specific genes involved in this disease are yet to be identified.


  3. Reduced blood flow: Anything that restricts or reduces blood flow to the hip joint can potentially contribute to the development of Legg-Calvé-Perthes disease. This includes conditions such as sickle cell anemia, clotting disorders, and certain vascular abnormalities. These conditions can impair the delivery of oxygen and nutrients to the femoral head, leading to its deterioration.


  4. Environmental factors: While the exact environmental factors that may trigger Legg-Calvé-Perthes disease are not fully understood, some studies have suggested a possible link between the condition and certain lifestyle factors. Factors such as smoking during pregnancy, exposure to secondhand smoke, and poor nutrition have been proposed as potential contributors. However, more research is needed to establish a definitive connection.


  5. Age and gender: Legg-Calvé-Perthes disease primarily affects children between the ages of 4 and 10, with the peak incidence occurring around 6 years old. Boys are more commonly affected than girls, with a male-to-female ratio of approximately 4:1. The reasons behind these age and gender differences are not yet fully understood.



It is important to note that while these factors may contribute to the development of Legg-Calvé-Perthes disease, they do not guarantee its occurrence. Many children with one or more of these risk factors never develop the condition, while others without any known risk factors may still be affected.



Diagnosing Legg-Calvé-Perthes disease typically involves a combination of physical examination, medical history review, and imaging tests. X-rays, magnetic resonance imaging (MRI), and bone scans are commonly used to assess the extent of femoral head involvement and determine the stage of the disease.



Treatment for Legg-Calvé-Perthes disease aims to relieve symptoms, preserve hip joint function, and promote the healthy regrowth of the femoral head. The specific treatment approach may vary depending on the child's age, the stage of the disease, and the severity of symptoms. Non-surgical interventions such as rest, physical therapy, and the use of assistive devices (e.g., crutches) are often recommended to reduce pain, maintain mobility, and prevent further damage to the hip joint. In some cases, surgical interventions such as osteotomy (repositioning of the bone) or joint-preserving procedures may be necessary to correct deformities and improve long-term outcomes.



In conclusion, Legg-Calvé-Perthes disease is a complex condition with multiple potential causes. While impaired blood supply to the femoral head is the primary factor, genetic predisposition, reduced blood flow, environmental factors, and age/gender differences may also play a role. Further research is needed to fully understand the underlying mechanisms and develop more targeted prevention and treatment strategies for this condition.


Diseasemaps
3 answers
Eine Durchblutungsstörung der Hüftgelenke.

Wer umfangreiches und wertvolles Erfahrungswissen aus mehreren tausend Fällen benötigt, kann gern auf www.morbus-Perthes.de oder www.morbus-perthes.org Kontakt zu mir aufnehmen. Mein Name ist Wolfgang Strömich
There are no definitive causes.

Posted Mar 18, 2019 by Michael 2550

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LEGG-CALVÉ-PERTHES DISEASE STORIES
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Hi, I'm John, When I was 10 years old, in 1975, I was diagnosed with Legg Perthes.   I had a tough time with Legg Perthes as I was a bit too old for any real regrowth and recovery. I have walked with a limp my whole life since Legg Perthes visite...
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9 year old son diagnosed with Perthes Oct 2013
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My son born 2010 was diagnosed with Perthes May 2016.
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My son Jesse is age 9 and has Perthes In his Left hip, he was diagnosed over two years ago and is finally started walking again over the past two months after being in a broom stick cast for 3 months and a wheelchair for 18 months. Things are looking...
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Comencé teniendo dolor en la pierna derecha, en algunos casos no pude caminar por un tiempo. Paralelamente comencé a cojear por lo que visite diferentes médicos que lo diagnosticaron como un problema muscular. Finalmente, a los 8 años me sacaron ...

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Legg-Calvé-Perthes disease forum

LEGG-CALVÉ-PERTHES DISEASE FORUM
Legg-Calvé-Perthes disease forum
Hi! My name is Melina Morilla, I'm 16 years old, I'm from Arenys de Mar(Barcelona, Spain) and I'm doing secondary studies. I have to do a work and I decided to do it about Perthes disease, because I suffered from it. I would like to know if I could s...

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