Which are the symptoms of Lemierres syndrome?

Symptoms of Lemierre's Syndrome

Lemierre's syndrome, also known as postanginal sepsis, is a rare but potentially life-threatening condition that primarily affects young adults. It is characterized by the development of a deep neck infection, usually following a recent oropharyngeal infection, such as tonsillitis or pharyngitis. Lemierre's syndrome is caused by the bacterium Fusobacterium necrophorum, which is part of the normal flora in the oropharynx.

The symptoms of Lemierre's syndrome can vary depending on the stage of the infection and the organs involved. The condition typically progresses through several phases, each with its own set of symptoms:

Initial Infection Phase:

The initial infection phase of Lemierre's syndrome often presents with symptoms similar to a typical upper respiratory tract infection, such as:

• Sore throat


• Fever


• Swollen and tender lymph nodes in the neck


• Fatigue

These symptoms may be mistaken for a common cold or flu, leading to a delay in diagnosis.

Septicemia Phase:

If left untreated, Lemierre's syndrome can progress to the septicemia phase, which is characterized by the spread of infection to the bloodstream. During this phase, the symptoms become more severe and may include:

• High fever


• Rapid heart rate


• Chills and sweating


• Severe fatigue


• Generalized body aches


• Headache


• Joint pain


• Shortness of breath

At this stage, the infection can spread to various organs and tissues, leading to complications such as septic emboli, abscess formation, or pneumonia.

Metastatic Phase:

In the metastatic phase, the infection can spread to distant sites in the body, resulting in the development of abscesses or septic emboli. The symptoms during this phase may include:

• Chest pain


• Cough


• Difficulty breathing


• Swelling and pain in the joints


• Abdominal pain


• Nausea and vomiting

Complications in this phase can be life-threatening and require immediate medical attention.

Thrombophlebitis Phase:

In some cases, Lemierre's syndrome can lead to the development of thrombophlebitis, which is the inflammation of a vein with the formation of a blood clot. Symptoms of thrombophlebitis may include:

• Pain, tenderness, and swelling along the affected vein


• Redness and warmth over the vein


• Fever

Thrombophlebitis most commonly affects the internal jugular vein, which is located in the neck.

It is important to note that Lemierre's syndrome is a rare condition, and not all individuals with a throat infection will develop this syndrome. However, if you experience persistent or worsening symptoms after a recent oropharyngeal infection, it is crucial to seek medical attention promptly. Lemierre's syndrome requires early diagnosis and aggressive treatment with antibiotics and, in some cases, surgical intervention to prevent complications and improve outcomes.