What are the best treatments for Lichen Planus?

Treatments for Lichen Planus

Lichen planus is a chronic inflammatory skin condition that affects the skin, mucous membranes, hair, and nails. It is characterized by itchy, flat-topped, purple-colored bumps that can appear on various parts of the body. While the exact cause of lichen planus is unknown, it is believed to be an autoimmune disorder where the body's immune system mistakenly attacks its own cells.

Although there is no cure for lichen planus, several treatment options are available to manage the symptoms and provide relief. The choice of treatment depends on the severity of the condition, the areas affected, and the individual's overall health. Here are some of the best treatments for lichen planus:

1. Topical Corticosteroids

Topical corticosteroids are commonly prescribed as the first-line treatment for lichen planus. These medications help reduce inflammation, itching, and redness. They are available in various forms such as creams, ointments, gels, or sprays. The strength and duration of treatment depend on the severity of the lesions and the affected area. It is important to follow the prescribed instructions and gradually taper off the medication to avoid potential side effects.

2. Oral Corticosteroids

In severe cases of lichen planus, when topical corticosteroids alone are not sufficient, oral corticosteroids may be prescribed. These medications are taken by mouth and work to suppress the immune system's response. However, long-term use of oral corticosteroids can have significant side effects, so they are typically used for short periods and gradually tapered off.

3. Topical Calcineurin Inhibitors

Topical calcineurin inhibitors are an alternative to corticosteroids, especially in sensitive areas such as the face, genitals, or mucous membranes. These medications, including tacrolimus and pimecrolimus, help reduce inflammation and itching. They are generally well-tolerated and can be used for longer durations without the risk of skin thinning associated with corticosteroids.

4. Retinoids

Retinoids, such as acitretin, are derived from vitamin A and can be used in the treatment of lichen planus. They work by modulating the immune response and reducing inflammation. Retinoids are usually prescribed for severe cases or when other treatments have failed. Regular monitoring of liver function and lipid levels is necessary due to potential side effects.

5. Phototherapy

Phototherapy involves exposing the affected skin to specific wavelengths of ultraviolet light. This treatment can help reduce inflammation and itching associated with lichen planus. Narrowband ultraviolet B (NB-UVB) and psoralen plus ultraviolet A (PUVA) are the most commonly used phototherapy options. Phototherapy is typically administered in a controlled medical setting and requires multiple sessions over several weeks.

6. Immunosuppressants

In cases where lichen planus is severe and resistant to other treatments, immunosuppressant medications may be considered. These drugs work by suppressing the immune system to reduce inflammation. Examples of immunosuppressants used in lichen planus include methotrexate, cyclosporine, and mycophenolate mofetil. Due to their potential side effects, close monitoring and regular blood tests are necessary.

7. Symptomatic Relief

In addition to medical treatments, there are several measures that can provide symptomatic relief for individuals with lichen planus. These include:

• Oral antihistamines: These can help alleviate itching and promote better sleep.


• Topical numbing agents: Creams or ointments containing lidocaine or benzocaine can temporarily relieve itching and discomfort.


• Maintaining good oral hygiene: Regular brushing, flossing, and using a gentle mouthwash can help manage oral lichen planus.


• Avoiding triggers: Identifying and avoiding potential triggers, such as certain foods or medications, can help prevent flare-ups.


• Stress management: Stress reduction techniques, such as meditation or yoga, may help improve symptoms.

It is important to consult a dermatologist or healthcare professional for an accurate diagnosis and appropriate treatment plan for lichen planus. They can assess the severity of the condition and tailor the treatment approach to individual needs.