Lissencephaly is a rare neurological disorder characterized by a smooth brain surface instead of the normal folds and grooves. It affects approximately 1 in every 100,000 live births worldwide. The prevalence may vary across different populations and regions. Lissencephaly can result in severe developmental delays, intellectual disabilities, seizures, and other neurological complications. The condition is typically caused by genetic mutations that disrupt brain development during pregnancy. Early diagnosis and intervention are crucial for managing symptoms and providing appropriate support to individuals with lissencephaly.