Which are the causes of Lymphocytic Infiltrate of Jessner?

Lymphocytic infiltrate of Jessner, also known as Jessner lymphocytic infiltrate or Jessner-Kanof syndrome, is a rare chronic skin condition characterized by the presence of lymphocytes in the skin. The exact cause of this condition is not well understood, but several factors have been proposed as potential triggers.

1. Autoimmune response: It is believed that Jessner lymphocytic infiltrate may result from an abnormal immune response in which the body's immune system mistakenly attacks its own healthy skin cells. This autoimmune response leads to the infiltration of lymphocytes into the skin, causing the characteristic skin lesions.

2. Genetic predisposition: Some studies suggest that there may be a genetic component to Jessner lymphocytic infiltrate. Certain genetic factors may make individuals more susceptible to developing this condition. However, more research is needed to fully understand the genetic basis of this condition.

3. Environmental triggers: Environmental factors, such as exposure to certain chemicals or allergens, may play a role in triggering Jessner lymphocytic infiltrate. It is believed that these triggers can activate the immune system and lead to the infiltration of lymphocytes into the skin. However, specific environmental triggers have not been identified conclusively.

4. Infectious agents: Some researchers have proposed that certain infectious agents, such as viruses or bacteria, may be involved in the development of Jessner lymphocytic infiltrate. However, no specific infectious agent has been consistently associated with this condition.

5. Hormonal factors: Hormonal imbalances or changes in hormone levels have been suggested as potential contributors to Jessner lymphocytic infiltrate. Some cases of this condition have been reported to occur or worsen during pregnancy or menopause, indicating a possible hormonal influence.

6. Other autoimmune conditions: Jessner lymphocytic infiltrate has been observed in association with other autoimmune conditions, such as lupus erythematosus or Sjögren's syndrome. This suggests a possible link between these conditions and the development of Jessner lymphocytic infiltrate.

It is important to note that while these factors have been proposed as potential causes of Jessner lymphocytic infiltrate, the exact mechanisms underlying this condition remain unclear. Further research is needed to fully understand the causes and pathogenesis of this rare skin disorder.