Lymphocytic infiltrate of Jessner, also known as Jessner lymphocytic infiltrate or Jessner-Kanof syndrome, is a rare chronic skin disorder characterized by the presence of infiltrating lymphocytes in the skin. It primarily affects middle-aged adults, with a slight female predominance.
The exact cause of lymphocytic infiltrate of Jessner is unknown, but it is believed to be an autoimmune condition. It is thought to result from an abnormal immune response, where the body's immune system mistakenly attacks the skin cells, leading to the characteristic lymphocytic infiltrate.
The prognosis of lymphocytic infiltrate of Jessner is generally favorable. The condition is typically chronic and may persist for years, but it is not life-threatening. The symptoms of the disease can vary from mild to severe, with periods of remission and exacerbation.
Diagnosis of lymphocytic infiltrate of Jessner is usually made based on clinical presentation and skin biopsy findings. The skin biopsy reveals a dense infiltrate of lymphocytes in the upper dermis, with sparing of the epidermis.
Treatment options for lymphocytic infiltrate of Jessner aim to control symptoms and reduce inflammation. Topical corticosteroids, such as potent or superpotent steroids, are commonly used as first-line therapy. In more severe cases, systemic corticosteroids or other immunosuppressive agents may be prescribed.
It is important for individuals with lymphocytic infiltrate of Jessner to follow up regularly with their dermatologist to monitor the disease progression and response to treatment. With appropriate management, most patients experience improvement in symptoms and quality of life.