What is Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL) is a rare and aggressive form of non-Hodgkin lymphoma, a type of cancer that affects the lymphatic system. It primarily affects middle-aged to older adults, with a higher incidence in males. MCL originates from abnormal B-lymphocytes, a type of white blood cell, in the outer edge (mantle zone) of the lymph nodes.

One of the distinguishing features of MCL is the overexpression of a protein called cyclin D1, which promotes uncontrolled cell growth. This leads to the formation of tumors in various lymphoid tissues, including lymph nodes, bone marrow, spleen, and gastrointestinal tract.

Common symptoms of MCL include swollen lymph nodes, fatigue, weight loss, night sweats, and abdominal discomfort. Diagnosis involves a combination of physical examination, blood tests, imaging scans, and a biopsy of the affected tissue.

Treatment options for MCL depend on the stage and aggressiveness of the disease. They may include chemotherapy, immunotherapy, targeted therapy, stem cell transplant, or a combination of these approaches. While MCL is generally considered incurable, advancements in treatment have improved overall survival rates and quality of life for patients.