Which are the symptoms of Marshall syndrome - PFAPA?

Symptoms of Marshall Syndrome - PFAPA

Marshall Syndrome, also known as Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) syndrome, is a rare autoinflammatory disorder that primarily affects children. It is characterized by recurrent episodes of fever, mouth ulcers, sore throat, and swollen lymph nodes. The exact cause of Marshall Syndrome - PFAPA is unknown, but it is believed to have a genetic component.

Fever: One of the hallmark symptoms of Marshall Syndrome - PFAPA is recurrent episodes of high fever. These fevers typically occur at regular intervals, lasting for about 3-6 days. The fever spikes rapidly and can reach temperatures as high as 104°F (40°C). The fever is often accompanied by other symptoms such as mouth ulcers, sore throat, and swollen lymph nodes.

Mouth Ulcers: Another common symptom of Marshall Syndrome - PFAPA is the presence of painful mouth ulcers. These ulcers are typically round or oval-shaped and can appear on the tongue, gums, inside of the cheeks, or the back of the throat. They may be white or yellowish in color and can make eating and drinking uncomfortable for the affected individual.

Sore Throat: Individuals with Marshall Syndrome - PFAPA often experience recurrent episodes of sore throat. The throat may feel scratchy, painful, or swollen. The sore throat is usually accompanied by other symptoms such as fever and mouth ulcers.

Swollen Lymph Nodes: Swollen lymph nodes, also known as lymphadenopathy, are a common feature of Marshall Syndrome - PFAPA. The lymph nodes in the neck region, specifically the cervical lymph nodes, may become enlarged and tender during episodes of the syndrome. The swelling usually subsides between episodes.

Other Symptoms: In addition to the primary symptoms mentioned above, individuals with Marshall Syndrome - PFAPA may experience other associated symptoms. These can include fatigue, headache, abdominal pain, joint pain, and skin rashes. These symptoms are typically temporary and resolve once the episode subsides.

It is important to note that the symptoms of Marshall Syndrome - PFAPA can vary in severity and frequency among affected individuals. Some individuals may experience episodes every few weeks, while others may have longer intervals between episodes. The syndrome usually begins in early childhood, with symptoms appearing before the age of 5. In most cases, the symptoms resolve spontaneously by adolescence.

If you suspect that you or your child may have Marshall Syndrome - PFAPA, it is important to consult a healthcare professional for a proper diagnosis. The diagnosis is typically made based on the pattern of symptoms and ruling out other possible causes of recurrent fever and sore throat.

Treatment for Marshall Syndrome - PFAPA aims to manage the symptoms and reduce the frequency and severity of episodes. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen are commonly used to control fever and relieve pain. In some cases, corticosteroids may be prescribed during episodes to reduce inflammation. Tonsillectomy, the surgical removal of the tonsils, may be considered in severe cases or when episodes are frequent and significantly impact the individual's quality of life.

In conclusion, Marshall Syndrome - PFAPA is a rare autoinflammatory disorder characterized by recurrent episodes of fever, mouth ulcers, sore throat, and swollen lymph nodes. Prompt medical attention and appropriate management can help individuals with Marshall Syndrome - PFAPA lead a better quality of life.